The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis

The disintegrin metalloprotease ADAM17 has a critical role in intestinal inflammation and regeneration in mice, as illustrated by the dramatically increased susceptibility of ADAM17 hypomorphic (ADAM17(ex/ex)) mice to dextran sulfate sodium (DSS)-induced colitis. Similarly, necroptosis has been impl...

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Detalles Bibliográficos
Autores principales: Fuchslocher Chico, Johaiber, Falk-Paulsen, Maren, Luzius, Anne, Saggau, Carina, Ruder, Barbara, Bolik, Julia, Schmidt-Arras, Dirk, Linkermann, Andreas, Becker, Christoph, Rosenstiel, Philip, Rose-John, Stefan, Adam, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849186/
https://www.ncbi.nlm.nih.gov/pubmed/29560122
http://dx.doi.org/10.18632/oncotarget.24410

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