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The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital
OBJECTIVE: From November 24 to December 9, 2013, an outbreak of the influenza (flu) A (H3) virus occurred in a tertiary-care university hospital (1,014 beds). We herein report the prophylactic effect of anti-flu agents for controlling the flu outbreak. METHODS: We administered pre- or post-exposure...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849543/ https://www.ncbi.nlm.nih.gov/pubmed/29445061 http://dx.doi.org/10.2169/internalmedicine.8854-17 |
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author | Hagihara, Mao Kato, Yukiko Kurumiya, Ai Takahashi, Tomoko Sakata, Miki Kato, Hideo Sakanashi, Daisuke Yamada, Atsuko Suematsu, Hiroyuki Hirai, Jun Nishiyama, Naoya Koizumi, Yusuke Yamagishi, Yuka Mikamo, Hiroshige |
author_facet | Hagihara, Mao Kato, Yukiko Kurumiya, Ai Takahashi, Tomoko Sakata, Miki Kato, Hideo Sakanashi, Daisuke Yamada, Atsuko Suematsu, Hiroyuki Hirai, Jun Nishiyama, Naoya Koizumi, Yusuke Yamagishi, Yuka Mikamo, Hiroshige |
author_sort | Hagihara, Mao |
collection | PubMed |
description | OBJECTIVE: From November 24 to December 9, 2013, an outbreak of the influenza (flu) A (H3) virus occurred in a tertiary-care university hospital (1,014 beds). We herein report the prophylactic effect of anti-flu agents for controlling the flu outbreak. METHODS: We administered pre- or post-exposure prophylaxis with anti-flu agents in flu outbreak. To test the effectiveness of prophylaxis in a flu outbreak, we used the posterior mean of the reproductive value during the pre- and post-intervention period. We also simulated the probability distribution of new flu cases. We performed an analysis to quantify the strength of the intervention effect. RESULTS: A total of 97 people were diagnosed with flu before the intervention, and 7 were diagnosed after the intervention. A molecular analysis of the flu virus revealed that this outbreak was due to the flu A (H3) virus. A total of 3,702 people received prophylaxis. There was a significant reduction in the reproductive value from 1.89 [95% confidence interval (CI), 1.59 to 2.24] to 0.65 (95% CI, 0.02 to 1.00) after the intervention (p<0.001). CONCLUSION: Prophylaxis with anti-flu agents, along with prompt identification and isolation of infected individuals, was effective in reducing the impact of a flu outbreak in a hospital. |
format | Online Article Text |
id | pubmed-5849543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-58495432018-03-15 The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital Hagihara, Mao Kato, Yukiko Kurumiya, Ai Takahashi, Tomoko Sakata, Miki Kato, Hideo Sakanashi, Daisuke Yamada, Atsuko Suematsu, Hiroyuki Hirai, Jun Nishiyama, Naoya Koizumi, Yusuke Yamagishi, Yuka Mikamo, Hiroshige Intern Med Original Article OBJECTIVE: From November 24 to December 9, 2013, an outbreak of the influenza (flu) A (H3) virus occurred in a tertiary-care university hospital (1,014 beds). We herein report the prophylactic effect of anti-flu agents for controlling the flu outbreak. METHODS: We administered pre- or post-exposure prophylaxis with anti-flu agents in flu outbreak. To test the effectiveness of prophylaxis in a flu outbreak, we used the posterior mean of the reproductive value during the pre- and post-intervention period. We also simulated the probability distribution of new flu cases. We performed an analysis to quantify the strength of the intervention effect. RESULTS: A total of 97 people were diagnosed with flu before the intervention, and 7 were diagnosed after the intervention. A molecular analysis of the flu virus revealed that this outbreak was due to the flu A (H3) virus. A total of 3,702 people received prophylaxis. There was a significant reduction in the reproductive value from 1.89 [95% confidence interval (CI), 1.59 to 2.24] to 0.65 (95% CI, 0.02 to 1.00) after the intervention (p<0.001). CONCLUSION: Prophylaxis with anti-flu agents, along with prompt identification and isolation of infected individuals, was effective in reducing the impact of a flu outbreak in a hospital. The Japanese Society of Internal Medicine 2018-02-15 /pmc/articles/PMC5849543/ /pubmed/29445061 http://dx.doi.org/10.2169/internalmedicine.8854-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Hagihara, Mao Kato, Yukiko Kurumiya, Ai Takahashi, Tomoko Sakata, Miki Kato, Hideo Sakanashi, Daisuke Yamada, Atsuko Suematsu, Hiroyuki Hirai, Jun Nishiyama, Naoya Koizumi, Yusuke Yamagishi, Yuka Mikamo, Hiroshige The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital |
title | The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital |
title_full | The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital |
title_fullStr | The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital |
title_full_unstemmed | The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital |
title_short | The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital |
title_sort | prophylactic effect of anti-influenza agents for an influenza outbreak in a university hospital |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849543/ https://www.ncbi.nlm.nih.gov/pubmed/29445061 http://dx.doi.org/10.2169/internalmedicine.8854-17 |
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