Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement

No valid treatment for isolated myeloid sarcoma (IMS) has yet been established, and no thorough genetic examinations have been performed because of its low incidence and unique manner of development. We herein report a 34-year-old man with pancreatic IMS with t(8;21)/RUNX1-RUNX1T1 rearrangement. He...

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Autores principales: Tokunaga, Kenji, Yamamura, Ayako, Ueno, Shikiko, Kikukawa, Yoshitaka, Yamaguchi, Shunichiro, Hidaka, Michihiro, Matsuno, Naofumi, Kawaguchi, Tatsuya, Matsuoka, Masao, Okuno, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849554/
https://www.ncbi.nlm.nih.gov/pubmed/29151502
http://dx.doi.org/10.2169/internalmedicine.8912-17
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author Tokunaga, Kenji
Yamamura, Ayako
Ueno, Shikiko
Kikukawa, Yoshitaka
Yamaguchi, Shunichiro
Hidaka, Michihiro
Matsuno, Naofumi
Kawaguchi, Tatsuya
Matsuoka, Masao
Okuno, Yutaka
author_facet Tokunaga, Kenji
Yamamura, Ayako
Ueno, Shikiko
Kikukawa, Yoshitaka
Yamaguchi, Shunichiro
Hidaka, Michihiro
Matsuno, Naofumi
Kawaguchi, Tatsuya
Matsuoka, Masao
Okuno, Yutaka
author_sort Tokunaga, Kenji
collection PubMed
description No valid treatment for isolated myeloid sarcoma (IMS) has yet been established, and no thorough genetic examinations have been performed because of its low incidence and unique manner of development. We herein report a 34-year-old man with pancreatic IMS with t(8;21)/RUNX1-RUNX1T1 rearrangement. He was treated with high-dose cytarabine followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT). This is the first report of pancreatic IMS with t(8;21). Positron emission tomography/computed tomography and genetic study are useful for the diagnosis, and allo-HSCT achieved complete remission in this patient.
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spelling pubmed-58495542018-03-15 Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement Tokunaga, Kenji Yamamura, Ayako Ueno, Shikiko Kikukawa, Yoshitaka Yamaguchi, Shunichiro Hidaka, Michihiro Matsuno, Naofumi Kawaguchi, Tatsuya Matsuoka, Masao Okuno, Yutaka Intern Med Case Report No valid treatment for isolated myeloid sarcoma (IMS) has yet been established, and no thorough genetic examinations have been performed because of its low incidence and unique manner of development. We herein report a 34-year-old man with pancreatic IMS with t(8;21)/RUNX1-RUNX1T1 rearrangement. He was treated with high-dose cytarabine followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT). This is the first report of pancreatic IMS with t(8;21). Positron emission tomography/computed tomography and genetic study are useful for the diagnosis, and allo-HSCT achieved complete remission in this patient. The Japanese Society of Internal Medicine 2017-11-20 2018-02-15 /pmc/articles/PMC5849554/ /pubmed/29151502 http://dx.doi.org/10.2169/internalmedicine.8912-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tokunaga, Kenji
Yamamura, Ayako
Ueno, Shikiko
Kikukawa, Yoshitaka
Yamaguchi, Shunichiro
Hidaka, Michihiro
Matsuno, Naofumi
Kawaguchi, Tatsuya
Matsuoka, Masao
Okuno, Yutaka
Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement
title Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement
title_full Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement
title_fullStr Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement
title_full_unstemmed Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement
title_short Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement
title_sort isolated pancreatic myeloid sarcoma associated with t(8;21)/runx1-runx1t1 rearrangement
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849554/
https://www.ncbi.nlm.nih.gov/pubmed/29151502
http://dx.doi.org/10.2169/internalmedicine.8912-17
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