Acute Megakaryoblastic Leukemia Developing as Donor Cell Leukemia after Umbilical Cord Blood Transplantation

A 64-year-old man with acute myeloid leukemia underwent umbilical cord blood transplantation (UCBT). After 11 months of complete remission (CR) following UCBT, the bone marrow showed 7.5% myeloblasts. CR was obtained after a single course of azacitidine monotherapy, but the myeloblasts gradually inc...

Descripción completa

Detalles Bibliográficos
Autores principales: Adachi, Yoshitaka, Yamaguchi, Yohei, Sagou, Ken, Yamaga, Yusuke, Fukushima, Nobuaki, Ozeki, Kazutaka, Kohno, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849555/
https://www.ncbi.nlm.nih.gov/pubmed/29151503
http://dx.doi.org/10.2169/internalmedicine.9005-17
_version_ 1783306055943454720
author Adachi, Yoshitaka
Yamaguchi, Yohei
Sagou, Ken
Yamaga, Yusuke
Fukushima, Nobuaki
Ozeki, Kazutaka
Kohno, Akio
author_facet Adachi, Yoshitaka
Yamaguchi, Yohei
Sagou, Ken
Yamaga, Yusuke
Fukushima, Nobuaki
Ozeki, Kazutaka
Kohno, Akio
author_sort Adachi, Yoshitaka
collection PubMed
description A 64-year-old man with acute myeloid leukemia underwent umbilical cord blood transplantation (UCBT). After 11 months of complete remission (CR) following UCBT, the bone marrow showed 7.5% myeloblasts. CR was obtained after a single course of azacitidine monotherapy, but the myeloblasts gradually increased in the blood. We made a diagnosis of acute megakaryoblastic leukemia derived from donor cell with a fluorescence in situ hybridization (FISH) analysis of the sex chromosomes and an immunophenotypic analysis. Azacitidine was administered again and produced a therapeutic effect of stable disease. This case suggests that azacitidine may be a useful therapy for patients with acute megakaryoblastic leukemia in situations in which intensive chemotherapy and transplantation are not indicated.
format Online
Article
Text
id pubmed-5849555
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-58495552018-03-15 Acute Megakaryoblastic Leukemia Developing as Donor Cell Leukemia after Umbilical Cord Blood Transplantation Adachi, Yoshitaka Yamaguchi, Yohei Sagou, Ken Yamaga, Yusuke Fukushima, Nobuaki Ozeki, Kazutaka Kohno, Akio Intern Med Case Report A 64-year-old man with acute myeloid leukemia underwent umbilical cord blood transplantation (UCBT). After 11 months of complete remission (CR) following UCBT, the bone marrow showed 7.5% myeloblasts. CR was obtained after a single course of azacitidine monotherapy, but the myeloblasts gradually increased in the blood. We made a diagnosis of acute megakaryoblastic leukemia derived from donor cell with a fluorescence in situ hybridization (FISH) analysis of the sex chromosomes and an immunophenotypic analysis. Azacitidine was administered again and produced a therapeutic effect of stable disease. This case suggests that azacitidine may be a useful therapy for patients with acute megakaryoblastic leukemia in situations in which intensive chemotherapy and transplantation are not indicated. The Japanese Society of Internal Medicine 2017-11-20 2018-02-15 /pmc/articles/PMC5849555/ /pubmed/29151503 http://dx.doi.org/10.2169/internalmedicine.9005-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Adachi, Yoshitaka
Yamaguchi, Yohei
Sagou, Ken
Yamaga, Yusuke
Fukushima, Nobuaki
Ozeki, Kazutaka
Kohno, Akio
Acute Megakaryoblastic Leukemia Developing as Donor Cell Leukemia after Umbilical Cord Blood Transplantation
title Acute Megakaryoblastic Leukemia Developing as Donor Cell Leukemia after Umbilical Cord Blood Transplantation
title_full Acute Megakaryoblastic Leukemia Developing as Donor Cell Leukemia after Umbilical Cord Blood Transplantation
title_fullStr Acute Megakaryoblastic Leukemia Developing as Donor Cell Leukemia after Umbilical Cord Blood Transplantation
title_full_unstemmed Acute Megakaryoblastic Leukemia Developing as Donor Cell Leukemia after Umbilical Cord Blood Transplantation
title_short Acute Megakaryoblastic Leukemia Developing as Donor Cell Leukemia after Umbilical Cord Blood Transplantation
title_sort acute megakaryoblastic leukemia developing as donor cell leukemia after umbilical cord blood transplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849555/
https://www.ncbi.nlm.nih.gov/pubmed/29151503
http://dx.doi.org/10.2169/internalmedicine.9005-17
work_keys_str_mv AT adachiyoshitaka acutemegakaryoblasticleukemiadevelopingasdonorcellleukemiaafterumbilicalcordbloodtransplantation
AT yamaguchiyohei acutemegakaryoblasticleukemiadevelopingasdonorcellleukemiaafterumbilicalcordbloodtransplantation
AT sagouken acutemegakaryoblasticleukemiadevelopingasdonorcellleukemiaafterumbilicalcordbloodtransplantation
AT yamagayusuke acutemegakaryoblasticleukemiadevelopingasdonorcellleukemiaafterumbilicalcordbloodtransplantation
AT fukushimanobuaki acutemegakaryoblasticleukemiadevelopingasdonorcellleukemiaafterumbilicalcordbloodtransplantation
AT ozekikazutaka acutemegakaryoblasticleukemiadevelopingasdonorcellleukemiaafterumbilicalcordbloodtransplantation
AT kohnoakio acutemegakaryoblasticleukemiadevelopingasdonorcellleukemiaafterumbilicalcordbloodtransplantation

Ejemplares similares