miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

High-grade serous ovarian cancers (HGSOC) have been subdivided into molecular subtypes. The mesenchymal HGSOC subgroup, defined by stromal-related gene signatures, is invariably associated with poor patient survival. We demonstrate that stroma exerts a key function in mesenchymal HGSOC. We highlight...

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Detalles Bibliográficos
Autores principales: Givel, Anne-Marie, Kieffer, Yann, Scholer-Dahirel, Alix, Sirven, Philemon, Cardon, Melissa, Pelon, Floriane, Magagna, Ilaria, Gentric, Géraldine, Costa, Ana, Bonneau, Claire, Mieulet, Virginie, Vincent-Salomon, Anne, Mechta-Grigoriou, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849633/
https://www.ncbi.nlm.nih.gov/pubmed/29535360
http://dx.doi.org/10.1038/s41467-018-03348-z

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