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Blood Epstein–Barr virus DNA does not predict outcome in advanced HIV-associated Hodgkin lymphoma

In HIV-seronegative patients with advanced Hodgkin lymphoma (HL), Epstein–Barr virus (EBV) viraemia at diagnosis predicts a worse progression-free survival (PFS), independent of the International Prognostic Score. However, its role in HIV-associated HL is uncharacterised. We collected clinico-pathol...

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Autores principales: Ul-Haq, Ikram, Dalla Pria, Alessia, Suardi, Elisa, Pinato, David J., Froeling, Fieke, Forni, John, Randell, Paul, Bower, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849636/
https://www.ncbi.nlm.nih.gov/pubmed/29536181
http://dx.doi.org/10.1007/s12032-018-1099-2
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author Ul-Haq, Ikram
Dalla Pria, Alessia
Suardi, Elisa
Pinato, David J.
Froeling, Fieke
Forni, John
Randell, Paul
Bower, Mark
author_facet Ul-Haq, Ikram
Dalla Pria, Alessia
Suardi, Elisa
Pinato, David J.
Froeling, Fieke
Forni, John
Randell, Paul
Bower, Mark
author_sort Ul-Haq, Ikram
collection PubMed
description In HIV-seronegative patients with advanced Hodgkin lymphoma (HL), Epstein–Barr virus (EBV) viraemia at diagnosis predicts a worse progression-free survival (PFS), independent of the International Prognostic Score. However, its role in HIV-associated HL is uncharacterised. We collected clinico-pathologic and treatment data from a prospective series of 44 HIV-associated HLs from 2000 to 2016. We evaluated circulating EBV DNA as a prognostic factor on uni- and multivariable analyses in relationship to the International Prognostic Index criteria. In 44 patients with HIV-associated HL, EBV was detected by in situ hybridisation in all diagnostic biopsies. Blood EBV DNA was detectable in 26 patients (59%) with a median of 600 copies/mL (range 0–161,000). EBV DNA was independent of CD4 cell count (p = 0.9) or HIV viral load (p = 0.6) and did not predict PFS (HR 1.6, 95% CI 0.39–6.7, p = 0.49). EBV DNA is not a prognostic trait in HIV-associated HL. Prognostication in HIV-associated HL should be solely based on the International Prognostic Index criteria.
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spelling pubmed-58496362018-03-21 Blood Epstein–Barr virus DNA does not predict outcome in advanced HIV-associated Hodgkin lymphoma Ul-Haq, Ikram Dalla Pria, Alessia Suardi, Elisa Pinato, David J. Froeling, Fieke Forni, John Randell, Paul Bower, Mark Med Oncol Short Communication In HIV-seronegative patients with advanced Hodgkin lymphoma (HL), Epstein–Barr virus (EBV) viraemia at diagnosis predicts a worse progression-free survival (PFS), independent of the International Prognostic Score. However, its role in HIV-associated HL is uncharacterised. We collected clinico-pathologic and treatment data from a prospective series of 44 HIV-associated HLs from 2000 to 2016. We evaluated circulating EBV DNA as a prognostic factor on uni- and multivariable analyses in relationship to the International Prognostic Index criteria. In 44 patients with HIV-associated HL, EBV was detected by in situ hybridisation in all diagnostic biopsies. Blood EBV DNA was detectable in 26 patients (59%) with a median of 600 copies/mL (range 0–161,000). EBV DNA was independent of CD4 cell count (p = 0.9) or HIV viral load (p = 0.6) and did not predict PFS (HR 1.6, 95% CI 0.39–6.7, p = 0.49). EBV DNA is not a prognostic trait in HIV-associated HL. Prognostication in HIV-associated HL should be solely based on the International Prognostic Index criteria. Springer US 2018-03-13 2018 /pmc/articles/PMC5849636/ /pubmed/29536181 http://dx.doi.org/10.1007/s12032-018-1099-2 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Communication
Ul-Haq, Ikram
Dalla Pria, Alessia
Suardi, Elisa
Pinato, David J.
Froeling, Fieke
Forni, John
Randell, Paul
Bower, Mark
Blood Epstein–Barr virus DNA does not predict outcome in advanced HIV-associated Hodgkin lymphoma
title Blood Epstein–Barr virus DNA does not predict outcome in advanced HIV-associated Hodgkin lymphoma
title_full Blood Epstein–Barr virus DNA does not predict outcome in advanced HIV-associated Hodgkin lymphoma
title_fullStr Blood Epstein–Barr virus DNA does not predict outcome in advanced HIV-associated Hodgkin lymphoma
title_full_unstemmed Blood Epstein–Barr virus DNA does not predict outcome in advanced HIV-associated Hodgkin lymphoma
title_short Blood Epstein–Barr virus DNA does not predict outcome in advanced HIV-associated Hodgkin lymphoma
title_sort blood epstein–barr virus dna does not predict outcome in advanced hiv-associated hodgkin lymphoma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849636/
https://www.ncbi.nlm.nih.gov/pubmed/29536181
http://dx.doi.org/10.1007/s12032-018-1099-2
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