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In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics

PURPOSE: The purpose of the study is to investigate the enzyme(s) responsible for siponimod metabolism and to predict the inhibitory effects of fluconazole as well as the impact of cytochrome P450 (CYP) 2C9 genetic polymorphism on siponimod pharmacokinetics (PK) and metabolism. METHODS: In vitro met...

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Detalles Bibliográficos
Autores principales:	Jin, Yi, Borell, Hubert, Gardin, Anne, Ufer, Mike, Huth, Felix, Camenisch, Gian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Pharmacogenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849655/ https://www.ncbi.nlm.nih.gov/pubmed/29273968 http://dx.doi.org/10.1007/s00228-017-2404-2

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