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Direct coupling of detergent purified human mGlu(5) receptor to the heterotrimeric G proteins Gq and Gs

The metabotropic glutamate (mGlu) receptors are class C G protein-coupled receptors (GPCRs) that modulate synaptic activity and plasticity throughout the mammalian brain. Signal transduction is initiated by glutamate binding to the venus flytrap domains (VFT), which initiates a conformational change...

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Detalles Bibliográficos
Autores principales:	Nasrallah, Chady, Rottier, Karine, Marcellin, Romain, Compan, Vincent, Font, Joan, Llebaria, Amadeu, Pin, Jean-Philippe, Banères, Jean-Louis, Lebon, Guillaume
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849714/ https://www.ncbi.nlm.nih.gov/pubmed/29535347 http://dx.doi.org/10.1038/s41598-018-22729-4

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