Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions

Lipids are becoming known as essential allosteric modulators of G protein-coupled receptor (GPCRs). However, how they exert their effects on GPCR conformation at the atomic level is still unclear. In light of recent experimental data, we have performed several long-timescale molecular dynamics (MD)...

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Detalles Bibliográficos
Autores principales: Bruzzese, Agustín, Gil, Carles, Dalton, James A. R., Giraldo, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849739/
https://www.ncbi.nlm.nih.gov/pubmed/29535353
http://dx.doi.org/10.1038/s41598-018-22735-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849739/
https://www.ncbi.nlm.nih.gov/pubmed/29535353
http://dx.doi.org/10.1038/s41598-018-22735-6

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