Cargando…
Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions
Lipids are becoming known as essential allosteric modulators of G protein-coupled receptor (GPCRs). However, how they exert their effects on GPCR conformation at the atomic level is still unclear. In light of recent experimental data, we have performed several long-timescale molecular dynamics (MD)...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849739/ https://www.ncbi.nlm.nih.gov/pubmed/29535353 http://dx.doi.org/10.1038/s41598-018-22735-6 |