Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

Mutational inactivation of the SWI/SNF chromatin regulator ATRX occurs frequently in gliomas, the most common primary brain tumors. Whether and how ATRX deficiency promotes oncogenesis by epigenomic dysregulation remains unclear, despite its recent implication in both genomic instability and telomer...

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Detalles Bibliográficos
Autores principales: Danussi, Carla, Bose, Promita, Parthasarathy, Prasanna T., Silberman, Pedro C., Van Arnam, John S., Vitucci, Mark, Tang, Oliver Y., Heguy, Adriana, Wang, Yuxiang, Chan, Timothy A., Riggins, Gregory J., Sulman, Erik P., Lang, Frederick F., Creighton, Chad J., Deneen, Benjamin, Miller, C. Ryan, Picketts, David J., Kannan, Kasthuri, Huse, Jason T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849741/
https://www.ncbi.nlm.nih.gov/pubmed/29535300
http://dx.doi.org/10.1038/s41467-018-03476-6

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