Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer

Triple negative breast cancers (TNBCs) lack recurrent targetable driver mutations but demonstrate frequent copy number aberrations (CNAs). Here, we describe an integrative genomic and RNAi-based approach that identifies and validates gene addictions in TNBCs. CNAs and gene expression alterations are...

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Detalles Bibliográficos
Autores principales: Patel, Nirmesh, Weekes, Daniel, Drosopoulos, Konstantinos, Gazinska, Patrycja, Noel, Elodie, Rashid, Mamun, Mirza, Hasan, Quist, Jelmar, Brasó-Maristany, Fara, Mathew, Sumi, Ferro, Riccardo, Pereira, Ana Mendes, Prince, Cynthia, Noor, Farzana, Francesch-Domenech, Erika, Marlow, Rebecca, de Rinaldis, Emanuele, Grigoriadis, Anita, Linardopoulos, Spiros, Marra, Pierfrancesco, Tutt, Andrew N. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849766/
https://www.ncbi.nlm.nih.gov/pubmed/29535384
http://dx.doi.org/10.1038/s41467-018-03283-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849766/
https://www.ncbi.nlm.nih.gov/pubmed/29535384
http://dx.doi.org/10.1038/s41467-018-03283-z

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