Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling

Plk2 is a target of p53. Our previous studies demonstrated that with wild-type p53, Plk2 impacts mTOR signaling in the same manner as TSC1, and Plk2-deficient tumors grew larger than control. Other investigators have demonstrated that Plk2 phosphorylates mutant p53 in a positive feedback loop. We in...

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Detalles Bibliográficos
Autores principales: Matthew, Elizabeth M., Yang, Zhaohai, Peri, Suraj, Andrake, Mark, Dunbrack, Roland, Ross, Eric, El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849802/
https://www.ncbi.nlm.nih.gov/pubmed/29448085
http://dx.doi.org/10.1016/j.neo.2018.01.004

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