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Does intensity modulation increase target dose calculation errors of conventional algorithms for lung SBRT?

PURPOSE: Conventional dose algorithms (Type A and Type B) for lung SBRT can display considerable target dose errors compared to Type‐C algorithms. Intensity‐modulated techniques (IMRT/VMAT) are increasingly being utilized for lung SBRT. Therefore, our study aimed to assess whether intensity modulati...

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Autores principales: Zheng, Dandan, Verma, Vivek, Wang, Shuo, Liang, Xiaoying, Zhou, Sumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849821/
https://www.ncbi.nlm.nih.gov/pubmed/29388325
http://dx.doi.org/10.1002/acm2.12266
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author Zheng, Dandan
Verma, Vivek
Wang, Shuo
Liang, Xiaoying
Zhou, Sumin
author_facet Zheng, Dandan
Verma, Vivek
Wang, Shuo
Liang, Xiaoying
Zhou, Sumin
author_sort Zheng, Dandan
collection PubMed
description PURPOSE: Conventional dose algorithms (Type A and Type B) for lung SBRT can display considerable target dose errors compared to Type‐C algorithms. Intensity‐modulated techniques (IMRT/VMAT) are increasingly being utilized for lung SBRT. Therefore, our study aimed to assess whether intensity modulation increased target dose calculation errors by conventional algorithms over conformal techniques. METHODS: Twenty lung SBRT patients were parallely planned with both IMRT and dynamic conformal arc (DCA) techniques using a Type‐A algorithm, and another 20 patients were parallely planned with IMRT, VMAT, and DCA using a Type‐B algorithm. All 100 plans were recalculated with Type‐C algorithms using identical beam and monitor unit settings, with the Type‐A/Type‐B algorithm dose errors defined using Type‐C recalculation as the ground truth. Target dose errors for PTV and GTV were calculated for a variety of dosimetric end points. Using Wilcoxon signed‐rank tests (p < 0.05 for statistical significance), target dose errors were compared between corresponding IMRT/VMAT and DCA plans for the two conventional algorithms. The levels of intensity modulation were also evaluated using the ratios of MUs in the IMRT/VMAT plans to those in the corresponding DCA plans. Linear regression was used to study the correlation between intensity modulation and relative dose error magnitudes. RESULTS: Overall, larger errors were found for the Type‐A algorithm than for the Type‐B algorithm. However, the IMRT/VMAT plans were not found to have statistically larger dose errors from their corresponding DCA plans. Linear regression did not identify a significant correlation between the intensity modulation level and the relative dose error. CONCLUSION: Intensity modulation did not appear to increase target dose calculation errors for lung SBRT plans calculated with conventional algorithms.
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spelling pubmed-58498212018-04-02 Does intensity modulation increase target dose calculation errors of conventional algorithms for lung SBRT? Zheng, Dandan Verma, Vivek Wang, Shuo Liang, Xiaoying Zhou, Sumin J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: Conventional dose algorithms (Type A and Type B) for lung SBRT can display considerable target dose errors compared to Type‐C algorithms. Intensity‐modulated techniques (IMRT/VMAT) are increasingly being utilized for lung SBRT. Therefore, our study aimed to assess whether intensity modulation increased target dose calculation errors by conventional algorithms over conformal techniques. METHODS: Twenty lung SBRT patients were parallely planned with both IMRT and dynamic conformal arc (DCA) techniques using a Type‐A algorithm, and another 20 patients were parallely planned with IMRT, VMAT, and DCA using a Type‐B algorithm. All 100 plans were recalculated with Type‐C algorithms using identical beam and monitor unit settings, with the Type‐A/Type‐B algorithm dose errors defined using Type‐C recalculation as the ground truth. Target dose errors for PTV and GTV were calculated for a variety of dosimetric end points. Using Wilcoxon signed‐rank tests (p < 0.05 for statistical significance), target dose errors were compared between corresponding IMRT/VMAT and DCA plans for the two conventional algorithms. The levels of intensity modulation were also evaluated using the ratios of MUs in the IMRT/VMAT plans to those in the corresponding DCA plans. Linear regression was used to study the correlation between intensity modulation and relative dose error magnitudes. RESULTS: Overall, larger errors were found for the Type‐A algorithm than for the Type‐B algorithm. However, the IMRT/VMAT plans were not found to have statistically larger dose errors from their corresponding DCA plans. Linear regression did not identify a significant correlation between the intensity modulation level and the relative dose error. CONCLUSION: Intensity modulation did not appear to increase target dose calculation errors for lung SBRT plans calculated with conventional algorithms. John Wiley and Sons Inc. 2018-02-01 /pmc/articles/PMC5849821/ /pubmed/29388325 http://dx.doi.org/10.1002/acm2.12266 Text en © 2018 University of Nebraska Medical Center. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Zheng, Dandan
Verma, Vivek
Wang, Shuo
Liang, Xiaoying
Zhou, Sumin
Does intensity modulation increase target dose calculation errors of conventional algorithms for lung SBRT?
title Does intensity modulation increase target dose calculation errors of conventional algorithms for lung SBRT?
title_full Does intensity modulation increase target dose calculation errors of conventional algorithms for lung SBRT?
title_fullStr Does intensity modulation increase target dose calculation errors of conventional algorithms for lung SBRT?
title_full_unstemmed Does intensity modulation increase target dose calculation errors of conventional algorithms for lung SBRT?
title_short Does intensity modulation increase target dose calculation errors of conventional algorithms for lung SBRT?
title_sort does intensity modulation increase target dose calculation errors of conventional algorithms for lung sbrt?
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849821/
https://www.ncbi.nlm.nih.gov/pubmed/29388325
http://dx.doi.org/10.1002/acm2.12266
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