Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer

Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed apprecia...

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Detalles Bibliográficos
Autores principales: Moreira, Leticia, Bakir, Basil, Chatterji, Priya, Dantes, Zahra, Reichert, Maximilian, Rustgi, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849862/
https://www.ncbi.nlm.nih.gov/pubmed/29541683
http://dx.doi.org/10.1016/j.jcmgh.2017.12.004
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author Moreira, Leticia
Bakir, Basil
Chatterji, Priya
Dantes, Zahra
Reichert, Maximilian
Rustgi, Anil K.
author_facet Moreira, Leticia
Bakir, Basil
Chatterji, Priya
Dantes, Zahra
Reichert, Maximilian
Rustgi, Anil K.
author_sort Moreira, Leticia
collection PubMed
description Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed appreciably. This review summarizes a rapidly emerging model of pancreatic cancer research, focusing on 3-dimensional organoids as a powerful tool for several applications, but above all, representing a step toward personalized medicine.
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spelling pubmed-58498622018-03-14 Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer Moreira, Leticia Bakir, Basil Chatterji, Priya Dantes, Zahra Reichert, Maximilian Rustgi, Anil K. Cell Mol Gastroenterol Hepatol Review Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed appreciably. This review summarizes a rapidly emerging model of pancreatic cancer research, focusing on 3-dimensional organoids as a powerful tool for several applications, but above all, representing a step toward personalized medicine. Elsevier 2017-12-16 /pmc/articles/PMC5849862/ /pubmed/29541683 http://dx.doi.org/10.1016/j.jcmgh.2017.12.004 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Moreira, Leticia
Bakir, Basil
Chatterji, Priya
Dantes, Zahra
Reichert, Maximilian
Rustgi, Anil K.
Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
title Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
title_full Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
title_fullStr Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
title_full_unstemmed Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
title_short Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer
title_sort pancreas 3d organoids: current and future aspects as a research platform for personalized medicine in pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849862/
https://www.ncbi.nlm.nih.gov/pubmed/29541683
http://dx.doi.org/10.1016/j.jcmgh.2017.12.004
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