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Recent advances in antiviral interferon-stimulated gene biology
The interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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F1000 Research Limited
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850085/ https://www.ncbi.nlm.nih.gov/pubmed/29568506 http://dx.doi.org/10.12688/f1000research.12450.1 |
| _version_ | 1783306166033448960 |
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| author | Schoggins, John W. |
| author_facet | Schoggins, John W. |
| author_sort | Schoggins, John W. |
| collection | PubMed |
| description | The interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs are continually being identified, characterized mechanistically, and evaluated for protective roles in vivo. This review highlights selected recent findings of ISG effectors that contribute to our understanding of the interferon antiviral response. |
| format | Online Article Text |
| id | pubmed-5850085 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | F1000 Research Limited |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-58500852018-03-21 Recent advances in antiviral interferon-stimulated gene biology Schoggins, John W. F1000Res Review The interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs are continually being identified, characterized mechanistically, and evaluated for protective roles in vivo. This review highlights selected recent findings of ISG effectors that contribute to our understanding of the interferon antiviral response. F1000 Research Limited 2018-03-12 /pmc/articles/PMC5850085/ /pubmed/29568506 http://dx.doi.org/10.12688/f1000research.12450.1 Text en Copyright: © 2018 Schoggins JW http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Schoggins, John W. Recent advances in antiviral interferon-stimulated gene biology |
| title | Recent advances in antiviral interferon-stimulated gene biology |
| title_full | Recent advances in antiviral interferon-stimulated gene biology |
| title_fullStr | Recent advances in antiviral interferon-stimulated gene biology |
| title_full_unstemmed | Recent advances in antiviral interferon-stimulated gene biology |
| title_short | Recent advances in antiviral interferon-stimulated gene biology |
| title_sort | recent advances in antiviral interferon-stimulated gene biology |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850085/ https://www.ncbi.nlm.nih.gov/pubmed/29568506 http://dx.doi.org/10.12688/f1000research.12450.1 |
| work_keys_str_mv | AT schogginsjohnw recentadvancesinantiviralinterferonstimulatedgenebiology |