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Sex disparity in viral load, inflammation and liver damage in transgenic mice carrying full hepatitis B virus genome with the W4P mutation in the preS1 region

AIM: To study sex disparity in susceptibility to hepatocellular carcinoma (HCC), we created a transgenic mouse model that expressed the full hepatitis B virus (HBV) genome with the W4P mutation. METHODS: Transgenic mice were generated by transferring the pHY92-1.1x-HBV-full genome plasmid (genotype...

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Detalles Bibliográficos
Autores principales:	Lee, Seoung-Ae, Lee, So-Young, Choi, Yu-Min, Kim, Hong, Kim, Bum-Joon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2018
Materias:	Basic Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850128/ https://www.ncbi.nlm.nih.gov/pubmed/29563753 http://dx.doi.org/10.3748/wjg.v24.i10.1084

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