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Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections

Actin filaments, microtubules and intermediate filaments form the cytoskeleton of vertebrate cells. Involved in maintaining cell integrity and structure, facilitating cargo and vesicle transport, remodelling surface structures and motility, the cytoskeleton is necessary for the successful life of a...

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Detalles Bibliográficos
Autores principales: Denes, Christopher E., Miranda-Saksena, Monica, Cunningham, Anthony L., Diefenbach, Russell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850386/
https://www.ncbi.nlm.nih.gov/pubmed/29438303
http://dx.doi.org/10.3390/v10020079
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author Denes, Christopher E.
Miranda-Saksena, Monica
Cunningham, Anthony L.
Diefenbach, Russell J.
author_facet Denes, Christopher E.
Miranda-Saksena, Monica
Cunningham, Anthony L.
Diefenbach, Russell J.
author_sort Denes, Christopher E.
collection PubMed
description Actin filaments, microtubules and intermediate filaments form the cytoskeleton of vertebrate cells. Involved in maintaining cell integrity and structure, facilitating cargo and vesicle transport, remodelling surface structures and motility, the cytoskeleton is necessary for the successful life of a cell. Because of the broad range of functions these filaments are involved in, they are common targets for viral pathogens, including the alphaherpesviruses. Human-tropic alphaherpesviruses are prevalent pathogens carried by more than half of the world’s population; comprising herpes simplex virus (types 1 and 2) and varicella-zoster virus, these viruses are characterised by their ability to establish latency in sensory neurons. This review will discuss the known mechanisms involved in subversion of and transport via the cytoskeleton during alphaherpesvirus infections, focusing on protein-protein interactions and pathways that have recently been identified. Studies on related alphaherpesviruses whose primary host is not human, along with comparisons to more distantly related beta and gammaherpesviruses, are also presented in this review. The need to decipher as-yet-unknown mechanisms exploited by viruses to hijack cytoskeletal components—to reveal the hidden cytoskeletons in the closet—will also be addressed.
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spelling pubmed-58503862018-03-16 Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections Denes, Christopher E. Miranda-Saksena, Monica Cunningham, Anthony L. Diefenbach, Russell J. Viruses Review Actin filaments, microtubules and intermediate filaments form the cytoskeleton of vertebrate cells. Involved in maintaining cell integrity and structure, facilitating cargo and vesicle transport, remodelling surface structures and motility, the cytoskeleton is necessary for the successful life of a cell. Because of the broad range of functions these filaments are involved in, they are common targets for viral pathogens, including the alphaherpesviruses. Human-tropic alphaherpesviruses are prevalent pathogens carried by more than half of the world’s population; comprising herpes simplex virus (types 1 and 2) and varicella-zoster virus, these viruses are characterised by their ability to establish latency in sensory neurons. This review will discuss the known mechanisms involved in subversion of and transport via the cytoskeleton during alphaherpesvirus infections, focusing on protein-protein interactions and pathways that have recently been identified. Studies on related alphaherpesviruses whose primary host is not human, along with comparisons to more distantly related beta and gammaherpesviruses, are also presented in this review. The need to decipher as-yet-unknown mechanisms exploited by viruses to hijack cytoskeletal components—to reveal the hidden cytoskeletons in the closet—will also be addressed. MDPI 2018-02-13 /pmc/articles/PMC5850386/ /pubmed/29438303 http://dx.doi.org/10.3390/v10020079 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Denes, Christopher E.
Miranda-Saksena, Monica
Cunningham, Anthony L.
Diefenbach, Russell J.
Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections
title Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections
title_full Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections
title_fullStr Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections
title_full_unstemmed Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections
title_short Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections
title_sort cytoskeletons in the closet—subversion in alphaherpesvirus infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850386/
https://www.ncbi.nlm.nih.gov/pubmed/29438303
http://dx.doi.org/10.3390/v10020079
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