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The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses

C. elegans is an invaluable model organism that has been a driving force in many fundamental biological discoveries. However, it is only in the past two decades that it has been applied to host–pathogen interaction studies. These studies have been facilitated by the discoveries of natural microbes t...

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Detalles Bibliográficos
Autores principales: Jiang, Hongbing, Wang, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850392/
https://www.ncbi.nlm.nih.gov/pubmed/29443938
http://dx.doi.org/10.3390/v10020085
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author Jiang, Hongbing
Wang, David
author_facet Jiang, Hongbing
Wang, David
author_sort Jiang, Hongbing
collection PubMed
description C. elegans is an invaluable model organism that has been a driving force in many fundamental biological discoveries. However, it is only in the past two decades that it has been applied to host–pathogen interaction studies. These studies have been facilitated by the discoveries of natural microbes that infect C. elegans, including bacteria, fungi and viruses. Notably, many of these microbes share a common site of infection, the C. elegans intestine. Furthermore, the recent descriptions of a natural gut microbiota in C. elegans raise the possibility that this could be a novel model system for microbiome and trans-kingdom interaction studies. Here we review studies of C. elegans host–microbe interactions with a particular focus on the intestine.
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spelling pubmed-58503922018-03-16 The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses Jiang, Hongbing Wang, David Viruses Review C. elegans is an invaluable model organism that has been a driving force in many fundamental biological discoveries. However, it is only in the past two decades that it has been applied to host–pathogen interaction studies. These studies have been facilitated by the discoveries of natural microbes that infect C. elegans, including bacteria, fungi and viruses. Notably, many of these microbes share a common site of infection, the C. elegans intestine. Furthermore, the recent descriptions of a natural gut microbiota in C. elegans raise the possibility that this could be a novel model system for microbiome and trans-kingdom interaction studies. Here we review studies of C. elegans host–microbe interactions with a particular focus on the intestine. MDPI 2018-02-14 /pmc/articles/PMC5850392/ /pubmed/29443938 http://dx.doi.org/10.3390/v10020085 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jiang, Hongbing
Wang, David
The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses
title The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses
title_full The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses
title_fullStr The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses
title_full_unstemmed The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses
title_short The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses
title_sort microbial zoo in the c. elegans intestine: bacteria, fungi and viruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850392/
https://www.ncbi.nlm.nih.gov/pubmed/29443938
http://dx.doi.org/10.3390/v10020085
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