Cargando…
The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses
C. elegans is an invaluable model organism that has been a driving force in many fundamental biological discoveries. However, it is only in the past two decades that it has been applied to host–pathogen interaction studies. These studies have been facilitated by the discoveries of natural microbes t...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850392/ https://www.ncbi.nlm.nih.gov/pubmed/29443938 http://dx.doi.org/10.3390/v10020085 |
_version_ | 1783306227553402880 |
---|---|
author | Jiang, Hongbing Wang, David |
author_facet | Jiang, Hongbing Wang, David |
author_sort | Jiang, Hongbing |
collection | PubMed |
description | C. elegans is an invaluable model organism that has been a driving force in many fundamental biological discoveries. However, it is only in the past two decades that it has been applied to host–pathogen interaction studies. These studies have been facilitated by the discoveries of natural microbes that infect C. elegans, including bacteria, fungi and viruses. Notably, many of these microbes share a common site of infection, the C. elegans intestine. Furthermore, the recent descriptions of a natural gut microbiota in C. elegans raise the possibility that this could be a novel model system for microbiome and trans-kingdom interaction studies. Here we review studies of C. elegans host–microbe interactions with a particular focus on the intestine. |
format | Online Article Text |
id | pubmed-5850392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58503922018-03-16 The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses Jiang, Hongbing Wang, David Viruses Review C. elegans is an invaluable model organism that has been a driving force in many fundamental biological discoveries. However, it is only in the past two decades that it has been applied to host–pathogen interaction studies. These studies have been facilitated by the discoveries of natural microbes that infect C. elegans, including bacteria, fungi and viruses. Notably, many of these microbes share a common site of infection, the C. elegans intestine. Furthermore, the recent descriptions of a natural gut microbiota in C. elegans raise the possibility that this could be a novel model system for microbiome and trans-kingdom interaction studies. Here we review studies of C. elegans host–microbe interactions with a particular focus on the intestine. MDPI 2018-02-14 /pmc/articles/PMC5850392/ /pubmed/29443938 http://dx.doi.org/10.3390/v10020085 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jiang, Hongbing Wang, David The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses |
title | The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses |
title_full | The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses |
title_fullStr | The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses |
title_full_unstemmed | The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses |
title_short | The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses |
title_sort | microbial zoo in the c. elegans intestine: bacteria, fungi and viruses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850392/ https://www.ncbi.nlm.nih.gov/pubmed/29443938 http://dx.doi.org/10.3390/v10020085 |
work_keys_str_mv | AT jianghongbing themicrobialzoointhecelegansintestinebacteriafungiandviruses AT wangdavid themicrobialzoointhecelegansintestinebacteriafungiandviruses AT jianghongbing microbialzoointhecelegansintestinebacteriafungiandviruses AT wangdavid microbialzoointhecelegansintestinebacteriafungiandviruses |