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The Alphavirus Exit Pathway: What We Know and What We Wish We Knew
Alphaviruses are enveloped positive sense RNA viruses and include serious human pathogens, such as the encephalitic alphaviruses and Chikungunya virus. Alphaviruses are transmitted to humans primarily by mosquito vectors and include species that are classified as emerging pathogens. Alphaviruses ass...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850396/ https://www.ncbi.nlm.nih.gov/pubmed/29470397 http://dx.doi.org/10.3390/v10020089 |
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author | Brown, Rebecca S. Wan, Judy J. Kielian, Margaret |
author_facet | Brown, Rebecca S. Wan, Judy J. Kielian, Margaret |
author_sort | Brown, Rebecca S. |
collection | PubMed |
description | Alphaviruses are enveloped positive sense RNA viruses and include serious human pathogens, such as the encephalitic alphaviruses and Chikungunya virus. Alphaviruses are transmitted to humans primarily by mosquito vectors and include species that are classified as emerging pathogens. Alphaviruses assemble highly organized, spherical particles that bud from the plasma membrane. In this review, we discuss what is known about the alphavirus exit pathway during a cellular infection. We describe the viral protein interactions that are critical for virus assembly/budding and the host factors that are involved, and we highlight the recent discovery of cell-to-cell transmission of alphavirus particles via intercellular extensions. Lastly, we discuss outstanding questions in the alphavirus exit pathway that may provide important avenues for future research. |
format | Online Article Text |
id | pubmed-5850396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58503962018-03-16 The Alphavirus Exit Pathway: What We Know and What We Wish We Knew Brown, Rebecca S. Wan, Judy J. Kielian, Margaret Viruses Review Alphaviruses are enveloped positive sense RNA viruses and include serious human pathogens, such as the encephalitic alphaviruses and Chikungunya virus. Alphaviruses are transmitted to humans primarily by mosquito vectors and include species that are classified as emerging pathogens. Alphaviruses assemble highly organized, spherical particles that bud from the plasma membrane. In this review, we discuss what is known about the alphavirus exit pathway during a cellular infection. We describe the viral protein interactions that are critical for virus assembly/budding and the host factors that are involved, and we highlight the recent discovery of cell-to-cell transmission of alphavirus particles via intercellular extensions. Lastly, we discuss outstanding questions in the alphavirus exit pathway that may provide important avenues for future research. MDPI 2018-02-22 /pmc/articles/PMC5850396/ /pubmed/29470397 http://dx.doi.org/10.3390/v10020089 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Brown, Rebecca S. Wan, Judy J. Kielian, Margaret The Alphavirus Exit Pathway: What We Know and What We Wish We Knew |
title | The Alphavirus Exit Pathway: What We Know and What We Wish We Knew |
title_full | The Alphavirus Exit Pathway: What We Know and What We Wish We Knew |
title_fullStr | The Alphavirus Exit Pathway: What We Know and What We Wish We Knew |
title_full_unstemmed | The Alphavirus Exit Pathway: What We Know and What We Wish We Knew |
title_short | The Alphavirus Exit Pathway: What We Know and What We Wish We Knew |
title_sort | alphavirus exit pathway: what we know and what we wish we knew |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850396/ https://www.ncbi.nlm.nih.gov/pubmed/29470397 http://dx.doi.org/10.3390/v10020089 |
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