Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing

We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.

Detalles Bibliográficos
Autores principales: Piantadosi, Anne, Kanjilal, Sanjat, Ganesh, Vijay, Khanna, Arjun, Hyle, Emily P, Rosand, Jonathan, Bold, Tyler, Metsky, Hayden C, Lemieux, Jacob, Leone, Michael J, Freimark, Lisa, Matranga, Christian B, Adams, Gordon, McGrath, Graham, Zamirpour, Siavash, Telford, Sam, Rosenberg, Eric, Cho, Tracey, Frosch, Matthew P, Goldberg, Marcia B, Mukerji, Shibani S, Sabeti, Pardis C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850433/
https://www.ncbi.nlm.nih.gov/pubmed/29020227
http://dx.doi.org/10.1093/cid/cix792
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author Piantadosi, Anne
Kanjilal, Sanjat
Ganesh, Vijay
Khanna, Arjun
Hyle, Emily P
Rosand, Jonathan
Bold, Tyler
Metsky, Hayden C
Lemieux, Jacob
Leone, Michael J
Freimark, Lisa
Matranga, Christian B
Adams, Gordon
McGrath, Graham
Zamirpour, Siavash
Telford, Sam
Rosenberg, Eric
Cho, Tracey
Frosch, Matthew P
Goldberg, Marcia B
Mukerji, Shibani S
Sabeti, Pardis C
author_facet Piantadosi, Anne
Kanjilal, Sanjat
Ganesh, Vijay
Khanna, Arjun
Hyle, Emily P
Rosand, Jonathan
Bold, Tyler
Metsky, Hayden C
Lemieux, Jacob
Leone, Michael J
Freimark, Lisa
Matranga, Christian B
Adams, Gordon
McGrath, Graham
Zamirpour, Siavash
Telford, Sam
Rosenberg, Eric
Cho, Tracey
Frosch, Matthew P
Goldberg, Marcia B
Mukerji, Shibani S
Sabeti, Pardis C
author_sort Piantadosi, Anne
collection PubMed
description We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.
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spelling pubmed-58504332018-03-23 Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing Piantadosi, Anne Kanjilal, Sanjat Ganesh, Vijay Khanna, Arjun Hyle, Emily P Rosand, Jonathan Bold, Tyler Metsky, Hayden C Lemieux, Jacob Leone, Michael J Freimark, Lisa Matranga, Christian B Adams, Gordon McGrath, Graham Zamirpour, Siavash Telford, Sam Rosenberg, Eric Cho, Tracey Frosch, Matthew P Goldberg, Marcia B Mukerji, Shibani S Sabeti, Pardis C Clin Infect Dis Brief Reports We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States. Oxford University Press 2018-03-01 2017-09-13 /pmc/articles/PMC5850433/ /pubmed/29020227 http://dx.doi.org/10.1093/cid/cix792 Text en © The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Piantadosi, Anne
Kanjilal, Sanjat
Ganesh, Vijay
Khanna, Arjun
Hyle, Emily P
Rosand, Jonathan
Bold, Tyler
Metsky, Hayden C
Lemieux, Jacob
Leone, Michael J
Freimark, Lisa
Matranga, Christian B
Adams, Gordon
McGrath, Graham
Zamirpour, Siavash
Telford, Sam
Rosenberg, Eric
Cho, Tracey
Frosch, Matthew P
Goldberg, Marcia B
Mukerji, Shibani S
Sabeti, Pardis C
Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing
title Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing
title_full Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing
title_fullStr Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing
title_full_unstemmed Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing
title_short Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing
title_sort rapid detection of powassan virus in a patient with encephalitis by metagenomic sequencing
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850433/
https://www.ncbi.nlm.nih.gov/pubmed/29020227
http://dx.doi.org/10.1093/cid/cix792
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