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A rare case of hemolytic disease of newborn due to weak D (D unknown) antigen in child

We are reporting a rare case of hemolytic disease of newborn with weak D antigen in child. A 3(rd) order male child of G(3)P(3)A(0) mother was admitted at 8(th) h of life with jaundice. Blood group of both mother and child were A Rh D negative. Baby's direct coombs test was positive. Weak D ant...

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Detalles Bibliográficos
Autores principales: Dava, Nirav Ramesh, Upadhyaya, Alok, Agarwal, Neha, Mehta, Amarjeet, Choudhary, Vijaypal, Goyal, Gourav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850702/
https://www.ncbi.nlm.nih.gov/pubmed/29563680
http://dx.doi.org/10.4103/ajts.AJTS_21_17
Descripción
Sumario:We are reporting a rare case of hemolytic disease of newborn with weak D antigen in child. A 3(rd) order male child of G(3)P(3)A(0) mother was admitted at 8(th) h of life with jaundice. Blood group of both mother and child were A Rh D negative. Baby's direct coombs test was positive. Weak D antigen was positive in baby. Hematological parameters showed all the signs of ongoing hemolysis, and the bilirubin level was in the zone of exchange transfusion. Exchange transfusion was done. An intravenous immunoglobulin was given to child after that. Mother had a history of first normal healthy male child with O Rh D positive blood group. Second male child expired on 3(rd) postnatal day due to bilirubin encephalopathy that had A Rh D negative blood group with positive direct coombs test.