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Population Heterogeneity in Mutation Rate Increases the Frequency of Higher-Order Mutants and Reduces Long-Term Mutational Load

Mutation rate is a crucial evolutionary parameter that has typically been treated as a constant in population genetic analyses. However, the propensity to mutate is likely to vary among co-existing individuals within a population, due to genetic polymorphisms, heterogeneous environmental influences,...

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Detalles Bibliográficos
Autores principales: Alexander, Helen K., Mayer, Stephanie I., Bonhoeffer, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850754/
https://www.ncbi.nlm.nih.gov/pubmed/27836985
http://dx.doi.org/10.1093/molbev/msw244

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