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Unbiased Estimate of Synonymous and Nonsynonymous Substitution Rates with Nonstationary Base Composition
The measurement of synonymous and nonsynonymous substitution rates (dS and dN) is useful for assessing selection operating on protein sequences or for investigating mutational processes affecting genomes. In particular, the ratio [Formula: see text] is expected to be a good proxy for ω, the ratio of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850866/ https://www.ncbi.nlm.nih.gov/pubmed/29220511 http://dx.doi.org/10.1093/molbev/msx308 |