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Ras enhances TGF-β signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1

BACKGROUND: Transformation by oncogene Ras overcomes TGF-β mediated growth inhibition in epithelial cells. However, it cooperates with each other to mediate epithelial to mesenchymal transition (EMT). The mechanism of how these two pathways interact with each other is controversial. METHODS: Molecul...

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Detalles Bibliográficos
Autores principales:	Liu, Sheng, Iaria, Josephine, Simpson, Richard J., Zhu, Hong-Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850916/ https://www.ncbi.nlm.nih.gov/pubmed/29534718 http://dx.doi.org/10.1186/s12964-018-0223-4

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