Cytoplasmic chromatin triggers inflammation in senescence and cancer

Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing(1–3). However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence(4,5), a form of terminal cell cycle arrest ass...

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Detalles Bibliográficos
Autores principales: Dou, Zhixun, Ghosh, Kanad, Vizioli, Maria Grazia, Zhu, Jiajun, Sen, Payel, Wangensteen, Kirk J., Simithy, Johayra, Lan, Yemin, Lin, Yanping, Zhou, Zhuo, Capell, Brian C., Xu, Caiyue, Xu, Mingang, Kieckhaefer, Julia E., Jiang, Tianying, Shoshkes-Carmel, Michal, Ahasan Al Tanim, K.M., Barber, Glen N., Seykora, John T., Millar, Sarah E., Kaestner, Klaus H., Garcia, Benjamin A., Adams, Peter D., Berger, Shelley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850938/
https://www.ncbi.nlm.nih.gov/pubmed/28976970
http://dx.doi.org/10.1038/nature24050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850938/
https://www.ncbi.nlm.nih.gov/pubmed/28976970
http://dx.doi.org/10.1038/nature24050

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