Cargando…
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing(1–3). However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence(4,5), a form of terminal cell cycle arrest ass...
Autores principales: | Dou, Zhixun, Ghosh, Kanad, Vizioli, Maria Grazia, Zhu, Jiajun, Sen, Payel, Wangensteen, Kirk J., Simithy, Johayra, Lan, Yemin, Lin, Yanping, Zhou, Zhuo, Capell, Brian C., Xu, Caiyue, Xu, Mingang, Kieckhaefer, Julia E., Jiang, Tianying, Shoshkes-Carmel, Michal, Ahasan Al Tanim, K.M., Barber, Glen N., Seykora, John T., Millar, Sarah E., Kaestner, Klaus H., Garcia, Benjamin A., Adams, Peter D., Berger, Shelley L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850938/ https://www.ncbi.nlm.nih.gov/pubmed/28976970 http://dx.doi.org/10.1038/nature24050 |
Ejemplares similares
-
Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials
por: Gordon, Sara, et al.
Publicado: (2015) -
Subepithelial telocytes are an important source of Wnts that supports intestinal crypts
por: Shoshkes-Carmel, Michal, et al.
Publicado: (2018) -
Lineage Tracing of FOXL1+ Cells in the Tunica Muscularis Suggests Mutual Origin for Telocytes and Smooth Muscle Cells
por: Shushan, Moriya, et al.
Publicado: (2022) -
HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity
por: Szigety, Katherine M., et al.
Publicado: (2020) -
In Vivo Screen Identifies Liver X Receptor Alpha Agonism Potentiates Sorafenib Killing of Hepatocellular Carcinoma
por: VÁZQUEZ SALGADO, A. M., et al.
Publicado: (2022)