SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT–receptor complex

Metastasis significantly reduces the survival rate of osteosarcoma (OS) patients. Therefore, identification of novel targets remains extremely important to prevent metastasis and treat OS. In this report, we show that SPARCL1 is downregulated in OS by epigenetic methylation of promoter DNA. In vitro...

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Detalles Bibliográficos
Autores principales: Zhao, S-J, Jiang, Y-Q, Xu, N-W, Li, Q, Zhang, Q, Wang, S-Y, Li, J, Wang, Y-H, Zhang, Y-L, Jiang, S-H, Wang, Y-J, Huang, Y-J, Zhang, X-X, Tian, G-A, Zhang, C-C, Lv, Y-Y, Dai, M, Liu, F, Zhang, R, Zhou, D, Zhang, Z-G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851113/
https://www.ncbi.nlm.nih.gov/pubmed/29084211
http://dx.doi.org/10.1038/onc.2017.403

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