Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia

Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH(+) subpopulations,...

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Detalles Bibliográficos
Autores principales: Peng, F, Wang, J-H, Fan, W-J, Meng, Y-T, Li, M-M, Li, T-T, Cui, B, Wang, H-F, Zhao, Y, An, F, Guo, T, Liu, X-F, Zhang, L, Lv, L, Lv, D-K, Xu, L-Z, Xie, J-J, Lin, W-X, Lam, E W-F, Xu, J, Liu, Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851116/
https://www.ncbi.nlm.nih.gov/pubmed/29106390
http://dx.doi.org/10.1038/onc.2017.368

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