Parenterally Administered Norovirus GII.4 Virus-Like Particle Vaccine Formulated with Aluminum Hydroxide or Monophosphoryl Lipid A Adjuvants Induces Systemic but Not Mucosal Immune Responses in Mice

Norovirus (NoV) is a main cause of acute gastroenteritis across all ages worldwide. NoV vaccine candidates currently in clinical trials are based on noninfectious highly immunogenic virus-like particles (VLPs) delivered intramuscularly (IM). Since NoV is an enteric pathogen, it is likely that mucosa...

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Detalles Bibliográficos
Autores principales: Heinimäki, Suvi, Malm, Maria, Vesikari, Timo, Blazevic, Vesna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851174/
https://www.ncbi.nlm.nih.gov/pubmed/29682589
http://dx.doi.org/10.1155/2018/3487095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851174/
https://www.ncbi.nlm.nih.gov/pubmed/29682589
http://dx.doi.org/10.1155/2018/3487095

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