Long non-coding RNA MIAT in development and disease: a new player in an old game

BACKGROUND: Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression of disease. MAIN BODY OF THE ABSTRACT: Myocardial infarction associated transcr...

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Detalles Bibliográficos
Autores principales: Sun, Cheng, Huang, Lining, Li, Zhenglong, Leng, Kaiming, Xu, Yi, Jiang, Xingming, Cui, Yunfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851271/
https://www.ncbi.nlm.nih.gov/pubmed/29534728
http://dx.doi.org/10.1186/s12929-018-0427-3
Descripción
Sumario:BACKGROUND: Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression of disease. MAIN BODY OF THE ABSTRACT: Myocardial infarction associated transcript (MIAT), which was recently found to demonstrate aberrant expression in various diseases, such as myocardial infarction, schizophrenia, ischemic stroke, diabetic complications, age-related cataract and cancers, is a novel disease-related lncRNA. This work summarize current evidence regarding the biological functions and underlying mechanisms of lncRNA MIAT during disease development. SHORT CONCLUSION: LncRNA MIAT likely represents a feasible cancer biomarker or therapeutic target.

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