Long non-coding RNA MIAT in development and disease: a new player in an old game

BACKGROUND: Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression of disease. MAIN BODY OF THE ABSTRACT: Myocardial infarction associated transcr...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Cheng, Huang, Lining, Li, Zhenglong, Leng, Kaiming, Xu, Yi, Jiang, Xingming, Cui, Yunfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851271/
https://www.ncbi.nlm.nih.gov/pubmed/29534728
http://dx.doi.org/10.1186/s12929-018-0427-3
_version_ 1783306364800466944
author Sun, Cheng
Huang, Lining
Li, Zhenglong
Leng, Kaiming
Xu, Yi
Jiang, Xingming
Cui, Yunfu
author_facet Sun, Cheng
Huang, Lining
Li, Zhenglong
Leng, Kaiming
Xu, Yi
Jiang, Xingming
Cui, Yunfu
author_sort Sun, Cheng
collection PubMed
description BACKGROUND: Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression of disease. MAIN BODY OF THE ABSTRACT: Myocardial infarction associated transcript (MIAT), which was recently found to demonstrate aberrant expression in various diseases, such as myocardial infarction, schizophrenia, ischemic stroke, diabetic complications, age-related cataract and cancers, is a novel disease-related lncRNA. This work summarize current evidence regarding the biological functions and underlying mechanisms of lncRNA MIAT during disease development. SHORT CONCLUSION: LncRNA MIAT likely represents a feasible cancer biomarker or therapeutic target.
format Online
Article
Text
id pubmed-5851271
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-58512712018-03-21 Long non-coding RNA MIAT in development and disease: a new player in an old game Sun, Cheng Huang, Lining Li, Zhenglong Leng, Kaiming Xu, Yi Jiang, Xingming Cui, Yunfu J Biomed Sci Review BACKGROUND: Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression of disease. MAIN BODY OF THE ABSTRACT: Myocardial infarction associated transcript (MIAT), which was recently found to demonstrate aberrant expression in various diseases, such as myocardial infarction, schizophrenia, ischemic stroke, diabetic complications, age-related cataract and cancers, is a novel disease-related lncRNA. This work summarize current evidence regarding the biological functions and underlying mechanisms of lncRNA MIAT during disease development. SHORT CONCLUSION: LncRNA MIAT likely represents a feasible cancer biomarker or therapeutic target. BioMed Central 2018-03-13 /pmc/articles/PMC5851271/ /pubmed/29534728 http://dx.doi.org/10.1186/s12929-018-0427-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Sun, Cheng
Huang, Lining
Li, Zhenglong
Leng, Kaiming
Xu, Yi
Jiang, Xingming
Cui, Yunfu
Long non-coding RNA MIAT in development and disease: a new player in an old game
title Long non-coding RNA MIAT in development and disease: a new player in an old game
title_full Long non-coding RNA MIAT in development and disease: a new player in an old game
title_fullStr Long non-coding RNA MIAT in development and disease: a new player in an old game
title_full_unstemmed Long non-coding RNA MIAT in development and disease: a new player in an old game
title_short Long non-coding RNA MIAT in development and disease: a new player in an old game
title_sort long non-coding rna miat in development and disease: a new player in an old game
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851271/
https://www.ncbi.nlm.nih.gov/pubmed/29534728
http://dx.doi.org/10.1186/s12929-018-0427-3
work_keys_str_mv AT suncheng longnoncodingrnamiatindevelopmentanddiseaseanewplayerinanoldgame
AT huanglining longnoncodingrnamiatindevelopmentanddiseaseanewplayerinanoldgame
AT lizhenglong longnoncodingrnamiatindevelopmentanddiseaseanewplayerinanoldgame
AT lengkaiming longnoncodingrnamiatindevelopmentanddiseaseanewplayerinanoldgame
AT xuyi longnoncodingrnamiatindevelopmentanddiseaseanewplayerinanoldgame
AT jiangxingming longnoncodingrnamiatindevelopmentanddiseaseanewplayerinanoldgame
AT cuiyunfu longnoncodingrnamiatindevelopmentanddiseaseanewplayerinanoldgame

Ejemplares similares