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Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog()

The human chaperonin complex is a ~ 1 MDa nanomachine composed of two octameric rings formed from eight similar but non-identical subunits called CCT. Here, we are elucidating the mechanism of a heritable CCT5 subunit mutation that causes profound neuropathy in humans. In previous work, we introduce...

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Detalles Bibliográficos
Autores principales:	Spigolon, Dario, Gallagher, D. Travis, Velazquez-Campoy, Adrian, Bulone, Donatella, Narang, Jatin, San Biagio, Pier Luigi, Cappello, Francesco, Macario, Alberto J.L., Conway de Macario, Everly, Robb, Frank T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851525/ https://www.ncbi.nlm.nih.gov/pubmed/29552646 http://dx.doi.org/10.1016/j.bbrep.2017.07.011

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