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Positron emission tomography/computed tomography scan of Vogt–Koyanagi–Harada syndrome with associated autoimmune thyroid disease: A case report and literature review

RATIONALE: Vogt–Koyanagi–Harada (VKH) syndrome is a rare disease and could be associated with autoimmune thyroid disease (AITD). This report was aimed to investigate the utility of (18)F-fludeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) for the diagnosis of VKH synd...

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Autores principales: Huang, Ke-Hao, Tai, Ming-Cheng, Lee, Lung-Chi, Weng, Tzu-Heng, Chen, Yi-Hao, Lin, Li-Fan, Chen, Jiann-Torng, Lu, Da-Wen, Chen, Ching-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851737/
https://www.ncbi.nlm.nih.gov/pubmed/29489658
http://dx.doi.org/10.1097/MD.0000000000010047
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author Huang, Ke-Hao
Tai, Ming-Cheng
Lee, Lung-Chi
Weng, Tzu-Heng
Chen, Yi-Hao
Lin, Li-Fan
Chen, Jiann-Torng
Lu, Da-Wen
Chen, Ching-Long
author_facet Huang, Ke-Hao
Tai, Ming-Cheng
Lee, Lung-Chi
Weng, Tzu-Heng
Chen, Yi-Hao
Lin, Li-Fan
Chen, Jiann-Torng
Lu, Da-Wen
Chen, Ching-Long
author_sort Huang, Ke-Hao
collection PubMed
description RATIONALE: Vogt–Koyanagi–Harada (VKH) syndrome is a rare disease and could be associated with autoimmune thyroid disease (AITD). This report was aimed to investigate the utility of (18)F-fludeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) for the diagnosis of VKH syndrome with AITD and to perform a literature review on the association between the 2 diseases. PATIENT CONCERNS: A 55-year-old woman without the history of ocular trauma suffered from chronic headache. She was presented with painful blurred vision of both eyes with headache for 2 weeks. Ophthalmic evaluations revealed panuveitis, exudative retinal detachment, and papilloedema in both eyes. The clinical symptoms and presentations are compatible with the diagnosis of VKH syndrome. Other examinations for intraocular infection, malignancy, and lupus choroidopathy were of negative results. The result of contrast-enhanced computed tomography (CT) of the brain was normal. Due to the history of cancer in the patient's families, a (18)F-FDG PET/CT whole-body scan was performed. The result indicated a focal of 2-fluoro-2-deoxy-d-glucose (FDG) uptake at the right upper lobe of the thyroid. Therefore, the patient's thyroid function was examined and the result indicated euthyroidism with detectable thyroid peroxidase/thyroglobulin antibodies. DIAGNOSES: VKH syndrome with associated AITD. INTERVENTIONS: Treatment with intravenous pulse systemic methylprednisolone (1000 mg daily) was prescribed for 3 days and then shifted gradually to tapered oral steroid medication. OUTCOMES: Symptoms of papillitis and serous retinal detachment of VKH syndrome was relieved after steroid treatment LESSONS: (18)F-fludeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) can be used for the effective diagnosis of VKH syndrome with AITD.
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spelling pubmed-58517372018-03-21 Positron emission tomography/computed tomography scan of Vogt–Koyanagi–Harada syndrome with associated autoimmune thyroid disease: A case report and literature review Huang, Ke-Hao Tai, Ming-Cheng Lee, Lung-Chi Weng, Tzu-Heng Chen, Yi-Hao Lin, Li-Fan Chen, Jiann-Torng Lu, Da-Wen Chen, Ching-Long Medicine (Baltimore) 5800 RATIONALE: Vogt–Koyanagi–Harada (VKH) syndrome is a rare disease and could be associated with autoimmune thyroid disease (AITD). This report was aimed to investigate the utility of (18)F-fludeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) for the diagnosis of VKH syndrome with AITD and to perform a literature review on the association between the 2 diseases. PATIENT CONCERNS: A 55-year-old woman without the history of ocular trauma suffered from chronic headache. She was presented with painful blurred vision of both eyes with headache for 2 weeks. Ophthalmic evaluations revealed panuveitis, exudative retinal detachment, and papilloedema in both eyes. The clinical symptoms and presentations are compatible with the diagnosis of VKH syndrome. Other examinations for intraocular infection, malignancy, and lupus choroidopathy were of negative results. The result of contrast-enhanced computed tomography (CT) of the brain was normal. Due to the history of cancer in the patient's families, a (18)F-FDG PET/CT whole-body scan was performed. The result indicated a focal of 2-fluoro-2-deoxy-d-glucose (FDG) uptake at the right upper lobe of the thyroid. Therefore, the patient's thyroid function was examined and the result indicated euthyroidism with detectable thyroid peroxidase/thyroglobulin antibodies. DIAGNOSES: VKH syndrome with associated AITD. INTERVENTIONS: Treatment with intravenous pulse systemic methylprednisolone (1000 mg daily) was prescribed for 3 days and then shifted gradually to tapered oral steroid medication. OUTCOMES: Symptoms of papillitis and serous retinal detachment of VKH syndrome was relieved after steroid treatment LESSONS: (18)F-fludeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) can be used for the effective diagnosis of VKH syndrome with AITD. Wolters Kluwer Health 2018-03-02 /pmc/articles/PMC5851737/ /pubmed/29489658 http://dx.doi.org/10.1097/MD.0000000000010047 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 5800
Huang, Ke-Hao
Tai, Ming-Cheng
Lee, Lung-Chi
Weng, Tzu-Heng
Chen, Yi-Hao
Lin, Li-Fan
Chen, Jiann-Torng
Lu, Da-Wen
Chen, Ching-Long
Positron emission tomography/computed tomography scan of Vogt–Koyanagi–Harada syndrome with associated autoimmune thyroid disease: A case report and literature review
title Positron emission tomography/computed tomography scan of Vogt–Koyanagi–Harada syndrome with associated autoimmune thyroid disease: A case report and literature review
title_full Positron emission tomography/computed tomography scan of Vogt–Koyanagi–Harada syndrome with associated autoimmune thyroid disease: A case report and literature review
title_fullStr Positron emission tomography/computed tomography scan of Vogt–Koyanagi–Harada syndrome with associated autoimmune thyroid disease: A case report and literature review
title_full_unstemmed Positron emission tomography/computed tomography scan of Vogt–Koyanagi–Harada syndrome with associated autoimmune thyroid disease: A case report and literature review
title_short Positron emission tomography/computed tomography scan of Vogt–Koyanagi–Harada syndrome with associated autoimmune thyroid disease: A case report and literature review
title_sort positron emission tomography/computed tomography scan of vogt–koyanagi–harada syndrome with associated autoimmune thyroid disease: a case report and literature review
topic 5800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851737/
https://www.ncbi.nlm.nih.gov/pubmed/29489658
http://dx.doi.org/10.1097/MD.0000000000010047
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