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Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro
Non-small cell lung cancer (NSCLC) is a major type of lung cancer, with the highest mortality rate in all cancers. For all stages of NSCLC, the five-year survival is less than fifteen percent. Epithelial-mesenchymal transition (EMT) is a significant process in tumor occurrence and development, in wh...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851900/ https://www.ncbi.nlm.nih.gov/pubmed/29551936 http://dx.doi.org/10.1016/j.sjbs.2017.11.028 |
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author | He, Jia |
author_facet | He, Jia |
author_sort | He, Jia |
collection | PubMed |
description | Non-small cell lung cancer (NSCLC) is a major type of lung cancer, with the highest mortality rate in all cancers. For all stages of NSCLC, the five-year survival is less than fifteen percent. Epithelial-mesenchymal transition (EMT) is a significant process in tumor occurrence and development, in which microRNAs may play an important role. In many cancers, microRNA-15's family member can act as suppressors or oncogenes of tumors; however, the relation between these microRNAs and EMT in lung cancer remains unclear. According to our study, miR-15a expression decreased in tumor tissues compared with than that in adjacent tissue samples. Knocking down miR-15a expression in NSCLC cells inhibited apoptosis and facilitated cell proliferation and invasion, and. Moreover, down-regulating miR-15a decreased the expression of an EMT-associated protein, E-cadherin, while increased those of vimentin, N-cadherin, and slug. |
format | Online Article Text |
id | pubmed-5851900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-58519002018-03-16 Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro He, Jia Saudi J Biol Sci Article Non-small cell lung cancer (NSCLC) is a major type of lung cancer, with the highest mortality rate in all cancers. For all stages of NSCLC, the five-year survival is less than fifteen percent. Epithelial-mesenchymal transition (EMT) is a significant process in tumor occurrence and development, in which microRNAs may play an important role. In many cancers, microRNA-15's family member can act as suppressors or oncogenes of tumors; however, the relation between these microRNAs and EMT in lung cancer remains unclear. According to our study, miR-15a expression decreased in tumor tissues compared with than that in adjacent tissue samples. Knocking down miR-15a expression in NSCLC cells inhibited apoptosis and facilitated cell proliferation and invasion, and. Moreover, down-regulating miR-15a decreased the expression of an EMT-associated protein, E-cadherin, while increased those of vimentin, N-cadherin, and slug. Elsevier 2017-12 2017-11-11 /pmc/articles/PMC5851900/ /pubmed/29551936 http://dx.doi.org/10.1016/j.sjbs.2017.11.028 Text en © 2017 Production and hosting by Elsevier B.V. on behalf of King Saud University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article He, Jia Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro |
title | Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro |
title_full | Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro |
title_fullStr | Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro |
title_full_unstemmed | Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro |
title_short | Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro |
title_sort | knocking down mir-15a expression promotes the occurrence and development and induces the emt of nsclc cells in vitro |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851900/ https://www.ncbi.nlm.nih.gov/pubmed/29551936 http://dx.doi.org/10.1016/j.sjbs.2017.11.028 |
work_keys_str_mv | AT hejia knockingdownmir15aexpressionpromotestheoccurrenceanddevelopmentandinducestheemtofnsclccellsinvitro |