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Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models
Ononitol monohydrate (OM) was isolated from Cassia tora L. leaves. The anti-inflammatory and analgesic activities of OM have been examined in male Wistar rats and mice. The efficacy of OM against inflammation was studied by using carrageenan-induced paw oedema, croton oil-induced ear oedema, acetic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851938/ https://www.ncbi.nlm.nih.gov/pubmed/29551947 http://dx.doi.org/10.1016/j.sjbs.2017.11.042 |
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author | Antonisamy, Paulrayer Dhanasekaran, Muniyappan Kim, Ha-Rim Jo, Sung-Gang Agastian, Paul Kwon, Kang-Beom |
author_facet | Antonisamy, Paulrayer Dhanasekaran, Muniyappan Kim, Ha-Rim Jo, Sung-Gang Agastian, Paul Kwon, Kang-Beom |
author_sort | Antonisamy, Paulrayer |
collection | PubMed |
description | Ononitol monohydrate (OM) was isolated from Cassia tora L. leaves. The anti-inflammatory and analgesic activities of OM have been examined in male Wistar rats and mice. The efficacy of OM against inflammation was studied by using carrageenan-induced paw oedema, croton oil-induced ear oedema, acetic acid-induced vascular permeability, cotton pellet-induced granuloma and adjuvant-induced arthritis. The analgesic activity of OM was assessed using the acetic acid-induced abdominal constriction response, formalin-induced paw licking response and the hot-plate test. In acute type inflammation models, maximum inhibitions of 50.69 and 61.06% (P < .05) were noted with 20 mg/kg of OM in carrageenan-induced hind paw oedema and croton oil-induced ear oedema, respectively. Treatment of OM (20 mg/kg) meaningfully (P < .05) reduced the granuloma tissue formation by cotton pellet study at a rate of 36.25%. OM (20 mg/kg) inhibited 53.64% of paw thickness in adjuvant-induced arthritis model. OM has also been produced significant (P < .05) analgesic activity in acetic acid-induced abdominal constriction response, formalin-induced paw licking response and in hot-plate test suggesting its peripheral and central analgesic potential. The outcomes of the present study proposed that OM influenced on the anti-inflammatory and analgesic activities. |
format | Online Article Text |
id | pubmed-5851938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-58519382018-03-16 Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models Antonisamy, Paulrayer Dhanasekaran, Muniyappan Kim, Ha-Rim Jo, Sung-Gang Agastian, Paul Kwon, Kang-Beom Saudi J Biol Sci Article Ononitol monohydrate (OM) was isolated from Cassia tora L. leaves. The anti-inflammatory and analgesic activities of OM have been examined in male Wistar rats and mice. The efficacy of OM against inflammation was studied by using carrageenan-induced paw oedema, croton oil-induced ear oedema, acetic acid-induced vascular permeability, cotton pellet-induced granuloma and adjuvant-induced arthritis. The analgesic activity of OM was assessed using the acetic acid-induced abdominal constriction response, formalin-induced paw licking response and the hot-plate test. In acute type inflammation models, maximum inhibitions of 50.69 and 61.06% (P < .05) were noted with 20 mg/kg of OM in carrageenan-induced hind paw oedema and croton oil-induced ear oedema, respectively. Treatment of OM (20 mg/kg) meaningfully (P < .05) reduced the granuloma tissue formation by cotton pellet study at a rate of 36.25%. OM (20 mg/kg) inhibited 53.64% of paw thickness in adjuvant-induced arthritis model. OM has also been produced significant (P < .05) analgesic activity in acetic acid-induced abdominal constriction response, formalin-induced paw licking response and in hot-plate test suggesting its peripheral and central analgesic potential. The outcomes of the present study proposed that OM influenced on the anti-inflammatory and analgesic activities. Elsevier 2017-12 2017-11-15 /pmc/articles/PMC5851938/ /pubmed/29551947 http://dx.doi.org/10.1016/j.sjbs.2017.11.042 Text en © 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Antonisamy, Paulrayer Dhanasekaran, Muniyappan Kim, Ha-Rim Jo, Sung-Gang Agastian, Paul Kwon, Kang-Beom Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models |
title | Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models |
title_full | Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models |
title_fullStr | Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models |
title_full_unstemmed | Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models |
title_short | Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models |
title_sort | anti-inflammatory and analgesic activity of ononitol monohydrate isolated from cassia tora l. in animal models |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851938/ https://www.ncbi.nlm.nih.gov/pubmed/29551947 http://dx.doi.org/10.1016/j.sjbs.2017.11.042 |
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