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Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models

Ononitol monohydrate (OM) was isolated from Cassia tora L. leaves. The anti-inflammatory and analgesic activities of OM have been examined in male Wistar rats and mice. The efficacy of OM against inflammation was studied by using carrageenan-induced paw oedema, croton oil-induced ear oedema, acetic...

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Autores principales: Antonisamy, Paulrayer, Dhanasekaran, Muniyappan, Kim, Ha-Rim, Jo, Sung-Gang, Agastian, Paul, Kwon, Kang-Beom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851938/
https://www.ncbi.nlm.nih.gov/pubmed/29551947
http://dx.doi.org/10.1016/j.sjbs.2017.11.042
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author Antonisamy, Paulrayer
Dhanasekaran, Muniyappan
Kim, Ha-Rim
Jo, Sung-Gang
Agastian, Paul
Kwon, Kang-Beom
author_facet Antonisamy, Paulrayer
Dhanasekaran, Muniyappan
Kim, Ha-Rim
Jo, Sung-Gang
Agastian, Paul
Kwon, Kang-Beom
author_sort Antonisamy, Paulrayer
collection PubMed
description Ononitol monohydrate (OM) was isolated from Cassia tora L. leaves. The anti-inflammatory and analgesic activities of OM have been examined in male Wistar rats and mice. The efficacy of OM against inflammation was studied by using carrageenan-induced paw oedema, croton oil-induced ear oedema, acetic acid-induced vascular permeability, cotton pellet-induced granuloma and adjuvant-induced arthritis. The analgesic activity of OM was assessed using the acetic acid-induced abdominal constriction response, formalin-induced paw licking response and the hot-plate test. In acute type inflammation models, maximum inhibitions of 50.69 and 61.06% (P < .05) were noted with 20 mg/kg of OM in carrageenan-induced hind paw oedema and croton oil-induced ear oedema, respectively. Treatment of OM (20 mg/kg) meaningfully (P < .05) reduced the granuloma tissue formation by cotton pellet study at a rate of 36.25%. OM (20 mg/kg) inhibited 53.64% of paw thickness in adjuvant-induced arthritis model. OM has also been produced significant (P < .05) analgesic activity in acetic acid-induced abdominal constriction response, formalin-induced paw licking response and in hot-plate test suggesting its peripheral and central analgesic potential. The outcomes of the present study proposed that OM influenced on the anti-inflammatory and analgesic activities.
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spelling pubmed-58519382018-03-16 Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models Antonisamy, Paulrayer Dhanasekaran, Muniyappan Kim, Ha-Rim Jo, Sung-Gang Agastian, Paul Kwon, Kang-Beom Saudi J Biol Sci Article Ononitol monohydrate (OM) was isolated from Cassia tora L. leaves. The anti-inflammatory and analgesic activities of OM have been examined in male Wistar rats and mice. The efficacy of OM against inflammation was studied by using carrageenan-induced paw oedema, croton oil-induced ear oedema, acetic acid-induced vascular permeability, cotton pellet-induced granuloma and adjuvant-induced arthritis. The analgesic activity of OM was assessed using the acetic acid-induced abdominal constriction response, formalin-induced paw licking response and the hot-plate test. In acute type inflammation models, maximum inhibitions of 50.69 and 61.06% (P < .05) were noted with 20 mg/kg of OM in carrageenan-induced hind paw oedema and croton oil-induced ear oedema, respectively. Treatment of OM (20 mg/kg) meaningfully (P < .05) reduced the granuloma tissue formation by cotton pellet study at a rate of 36.25%. OM (20 mg/kg) inhibited 53.64% of paw thickness in adjuvant-induced arthritis model. OM has also been produced significant (P < .05) analgesic activity in acetic acid-induced abdominal constriction response, formalin-induced paw licking response and in hot-plate test suggesting its peripheral and central analgesic potential. The outcomes of the present study proposed that OM influenced on the anti-inflammatory and analgesic activities. Elsevier 2017-12 2017-11-15 /pmc/articles/PMC5851938/ /pubmed/29551947 http://dx.doi.org/10.1016/j.sjbs.2017.11.042 Text en © 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Antonisamy, Paulrayer
Dhanasekaran, Muniyappan
Kim, Ha-Rim
Jo, Sung-Gang
Agastian, Paul
Kwon, Kang-Beom
Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models
title Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models
title_full Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models
title_fullStr Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models
title_full_unstemmed Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models
title_short Anti-inflammatory and analgesic activity of ononitol monohydrate isolated from Cassia tora L. in animal models
title_sort anti-inflammatory and analgesic activity of ononitol monohydrate isolated from cassia tora l. in animal models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851938/
https://www.ncbi.nlm.nih.gov/pubmed/29551947
http://dx.doi.org/10.1016/j.sjbs.2017.11.042
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