VKORC1 sequence variants associated with resistance to anticoagulant rodenticides in Irish populations of Rattus norvegicus and Mus musculus domesticus

While resistance to anticoagulant rodenticides is known to occur in many European populations of Norway rat and house mouse, to-date no data is available on the occurrence in Ireland of such resistance. No genetic evidence for the occurrence of resistance was found in 65 Norway rat samples analysed,...

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Autores principales: Mooney, Jean, Lynch, Mark R., Prescott, Colin V., Clegg, Tracy, Loughlin, Michael, Hannon, Bernard, Moore, Colm, Faulkner, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852000/
https://www.ncbi.nlm.nih.gov/pubmed/29540746
http://dx.doi.org/10.1038/s41598-018-22815-7
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author Mooney, Jean
Lynch, Mark R.
Prescott, Colin V.
Clegg, Tracy
Loughlin, Michael
Hannon, Bernard
Moore, Colm
Faulkner, Richard
author_facet Mooney, Jean
Lynch, Mark R.
Prescott, Colin V.
Clegg, Tracy
Loughlin, Michael
Hannon, Bernard
Moore, Colm
Faulkner, Richard
author_sort Mooney, Jean
collection PubMed
description While resistance to anticoagulant rodenticides is known to occur in many European populations of Norway rat and house mouse, to-date no data is available on the occurrence in Ireland of such resistance. No genetic evidence for the occurrence of resistance was found in 65 Norway rat samples analysed, indicative of an absence, or low prevalence, of resistance in rats in at least the Eastern region of the island of Ireland. The presence of two of the most commonly found amino acid substitutions Leu128Ser and Tyr139Cys associated with house mouse resistance to anticoagulant rodenticides was confirmed. The occurrence of two such mutations is indicative of the occurrence of resistance to anticoagulant rodenticides in house mice in the Eastern region of the island of Ireland.
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spelling pubmed-58520002018-03-21 VKORC1 sequence variants associated with resistance to anticoagulant rodenticides in Irish populations of Rattus norvegicus and Mus musculus domesticus Mooney, Jean Lynch, Mark R. Prescott, Colin V. Clegg, Tracy Loughlin, Michael Hannon, Bernard Moore, Colm Faulkner, Richard Sci Rep Article While resistance to anticoagulant rodenticides is known to occur in many European populations of Norway rat and house mouse, to-date no data is available on the occurrence in Ireland of such resistance. No genetic evidence for the occurrence of resistance was found in 65 Norway rat samples analysed, indicative of an absence, or low prevalence, of resistance in rats in at least the Eastern region of the island of Ireland. The presence of two of the most commonly found amino acid substitutions Leu128Ser and Tyr139Cys associated with house mouse resistance to anticoagulant rodenticides was confirmed. The occurrence of two such mutations is indicative of the occurrence of resistance to anticoagulant rodenticides in house mice in the Eastern region of the island of Ireland. Nature Publishing Group UK 2018-03-14 /pmc/articles/PMC5852000/ /pubmed/29540746 http://dx.doi.org/10.1038/s41598-018-22815-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Mooney, Jean
Lynch, Mark R.
Prescott, Colin V.
Clegg, Tracy
Loughlin, Michael
Hannon, Bernard
Moore, Colm
Faulkner, Richard
VKORC1 sequence variants associated with resistance to anticoagulant rodenticides in Irish populations of Rattus norvegicus and Mus musculus domesticus
title VKORC1 sequence variants associated with resistance to anticoagulant rodenticides in Irish populations of Rattus norvegicus and Mus musculus domesticus
title_full VKORC1 sequence variants associated with resistance to anticoagulant rodenticides in Irish populations of Rattus norvegicus and Mus musculus domesticus
title_fullStr VKORC1 sequence variants associated with resistance to anticoagulant rodenticides in Irish populations of Rattus norvegicus and Mus musculus domesticus
title_full_unstemmed VKORC1 sequence variants associated with resistance to anticoagulant rodenticides in Irish populations of Rattus norvegicus and Mus musculus domesticus
title_short VKORC1 sequence variants associated with resistance to anticoagulant rodenticides in Irish populations of Rattus norvegicus and Mus musculus domesticus
title_sort vkorc1 sequence variants associated with resistance to anticoagulant rodenticides in irish populations of rattus norvegicus and mus musculus domesticus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852000/
https://www.ncbi.nlm.nih.gov/pubmed/29540746
http://dx.doi.org/10.1038/s41598-018-22815-7
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