Cargando…
Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer
Photothermal therapy (PTT) is a promising cancer treatment modality, but PTT generally requires direct access to the source of light irradiation, thus precluding its utility against disseminated, metastatic tumors. Here, we demonstrate that PTT combined with chemotherapy can trigger potent anti-tumo...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852008/ https://www.ncbi.nlm.nih.gov/pubmed/29540781 http://dx.doi.org/10.1038/s41467-018-03473-9 |
_version_ | 1783306479015559168 |
---|---|
author | Nam, Jutaek Son, Sejin Ochyl, Lukasz J. Kuai, Rui Schwendeman, Anna Moon, James J. |
author_facet | Nam, Jutaek Son, Sejin Ochyl, Lukasz J. Kuai, Rui Schwendeman, Anna Moon, James J. |
author_sort | Nam, Jutaek |
collection | PubMed |
description | Photothermal therapy (PTT) is a promising cancer treatment modality, but PTT generally requires direct access to the source of light irradiation, thus precluding its utility against disseminated, metastatic tumors. Here, we demonstrate that PTT combined with chemotherapy can trigger potent anti-tumor immunity against disseminated tumors. Specifically, we have developed polydopamine-coated spiky gold nanoparticles as a new photothermal agent with extensive photothermal stability and efficiency. Strikingly, a single round of PTT combined with a sub-therapeutic dose of doxorubicin can elicit robust anti-tumor immune responses and eliminate local as well as untreated, distant tumors in >85% of animals bearing CT26 colon carcinoma. We also demonstrate their therapeutic efficacy against TC-1 submucosa-lung metastasis, a highly aggressive model for advanced head and neck squamous cell carcinoma (HNSCC). Our study sheds new light on a previously unrecognized, immunological facet of chemo-photothermal therapy and may lead to new therapeutic strategies against advanced cancer. |
format | Online Article Text |
id | pubmed-5852008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58520082018-03-16 Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer Nam, Jutaek Son, Sejin Ochyl, Lukasz J. Kuai, Rui Schwendeman, Anna Moon, James J. Nat Commun Article Photothermal therapy (PTT) is a promising cancer treatment modality, but PTT generally requires direct access to the source of light irradiation, thus precluding its utility against disseminated, metastatic tumors. Here, we demonstrate that PTT combined with chemotherapy can trigger potent anti-tumor immunity against disseminated tumors. Specifically, we have developed polydopamine-coated spiky gold nanoparticles as a new photothermal agent with extensive photothermal stability and efficiency. Strikingly, a single round of PTT combined with a sub-therapeutic dose of doxorubicin can elicit robust anti-tumor immune responses and eliminate local as well as untreated, distant tumors in >85% of animals bearing CT26 colon carcinoma. We also demonstrate their therapeutic efficacy against TC-1 submucosa-lung metastasis, a highly aggressive model for advanced head and neck squamous cell carcinoma (HNSCC). Our study sheds new light on a previously unrecognized, immunological facet of chemo-photothermal therapy and may lead to new therapeutic strategies against advanced cancer. Nature Publishing Group UK 2018-03-14 /pmc/articles/PMC5852008/ /pubmed/29540781 http://dx.doi.org/10.1038/s41467-018-03473-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Nam, Jutaek Son, Sejin Ochyl, Lukasz J. Kuai, Rui Schwendeman, Anna Moon, James J. Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer |
title | Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer |
title_full | Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer |
title_fullStr | Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer |
title_full_unstemmed | Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer |
title_short | Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer |
title_sort | chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852008/ https://www.ncbi.nlm.nih.gov/pubmed/29540781 http://dx.doi.org/10.1038/s41467-018-03473-9 |
work_keys_str_mv | AT namjutaek chemophotothermaltherapycombinationelicitsantitumorimmunityagainstadvancedmetastaticcancer AT sonsejin chemophotothermaltherapycombinationelicitsantitumorimmunityagainstadvancedmetastaticcancer AT ochyllukaszj chemophotothermaltherapycombinationelicitsantitumorimmunityagainstadvancedmetastaticcancer AT kuairui chemophotothermaltherapycombinationelicitsantitumorimmunityagainstadvancedmetastaticcancer AT schwendemananna chemophotothermaltherapycombinationelicitsantitumorimmunityagainstadvancedmetastaticcancer AT moonjamesj chemophotothermaltherapycombinationelicitsantitumorimmunityagainstadvancedmetastaticcancer |