Cargando…

Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis

As a protective envelope surrounding the bacterial cell, the peptidoglycan sacculus is a site of vulnerability and an antibiotic target. Peptidoglycan components, assembled in the cytoplasm, are shuttled across the membrane in a cycle that uses undecaprenyl-phosphate. A product of peptidoglycan synt...

Descripción completa

Detalles Bibliográficos
Autores principales:	El Ghachi, Meriem, Howe, Nicole, Huang, Chia-Ying, Olieric, Vincent, Warshamanage, Rangana, Touzé, Thierry, Weichert, Dietmar, Stansfeld, Phillip J., Wang, Meitian, Kerff, Fred, Caffrey, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852022/ https://www.ncbi.nlm.nih.gov/pubmed/29540682 http://dx.doi.org/10.1038/s41467-018-03477-5

Ejemplares similares

Membrane Topology and Biochemical Characterization of the Escherichia coli BacA Undecaprenyl-Pyrophosphate Phosphatase
por: Manat, Guillaume, et al.
Publicado: (2015)

Towards discovery of inhibitors of the undecaprenyl-pyrophosphate phosphatase BacA by virtual high-throughput screening
por: Jukič, Marko, et al.
Publicado: (2022)

HupA, the main undecaprenyl pyrophosphate and phosphatidylglycerol phosphate phosphatase in Helicobacter pylori is essential for colonization of the stomach
por: Gasiorowski, Elise, et al.
Publicado: (2019)

In situ serial crystallography for rapid de novo membrane protein structure determination
por: Huang, Chia-Ying, et al.
Publicado: (2018)

Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis
por: Jukič, Marko, et al.
Publicado: (2019)

Species Differences in Alternative Substrate Utilization by the Antibacterial Target Undecaprenyl Pyrophosphate Synthase
por: Dodbele, Samantha, et al.
Publicado: (2014)

In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures
por: Huang, Chia-Ying, et al.
Publicado: (2016)

Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase
por: Lee, Lac V., et al.
Publicado: (2010)

Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis
por: Wiktor, Maciej, et al.
Publicado: (2017)

Periplasmic phosphorylation of lipid A is linked to the synthesis of undecaprenyl phosphate
por: Touzé, Thierry, et al.
Publicado: (2008)

Structure-Based Inhibitors Exhibit Differential Activities against Helicobacter pylori and Escherichia coli Undecaprenyl Pyrophosphate Synthases
por: Kuo, Chih-Jung, et al.
Publicado: (2008)

Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand-bound Conformational States of Undecaprenyl Pyrophosphate Synthase, an Antibacterial Target
por: Sinko, William, et al.
Publicado: (2011)

Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b
por: Boes, Adrien, et al.
Publicado: (2020)

The bacterial cell division protein fragment (E)FtsN binds to and activates the major peptidoglycan synthase PBP1b
por: Boes, Adrien, et al.
Publicado: (2021)

EIGER detector: application in macromolecular crystallography
por: Casanas, Arnau, et al.
Publicado: (2016)

Automated data collection and real-time data analysis suite for serial synchrotron crystallography
por: Basu, Shibom, et al.
Publicado: (2019)

EMDA: A Python package for Electron Microscopy Data Analysis
por: Warshamanage, Rangana, et al.
Publicado: (2022)

Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients
por: Oluwole, Abraham O., et al.
Publicado: (2022)

Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads
por: Sinko, William, et al.
Publicado: (2014)

Undecaprenyl phosphate translocases confer conditional microbial fitness
por: Sit, Brandon, et al.
Publicado: (2022)

Genetic synergy in Acinetobacter baumannii undecaprenyl biosynthesis and maintenance of lipid asymmetry impacts outer membrane and antimicrobial resistance
por: Noel, Hannah R., et al.
Publicado: (2023)

Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling
por: Workman, Sean D., et al.
Publicado: (2018)

Ca(2+)-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
por: Grein, Fabian, et al.
Publicado: (2020)

Insight into the dual function of lipid phosphate phosphatase PgpB involved in two essential cell-envelope metabolic pathways in Escherichia coli
por: Tian, Xudong, et al.
Publicado: (2020)

Lipid Flippases for Bacterial Peptidoglycan Biosynthesis
por: Ruiz, Natividad
Publicado: (2016)

3D-printed holders for in meso in situ fixed-target serial X-ray crystallography
por: Huang, Chia-Ying, et al.
Publicado: (2020)

Biosynthesis and possible functions of inositol pyrophosphates in plants
por: Williams, Sarah P., et al.
Publicado: (2015)

Pectocin M1 (PcaM1) Inhibits Escherichia coli Cell Growth and Peptidoglycan Biosynthesis through Periplasmic Expression
por: Chérier, Dimitri, et al.
Publicado: (2016)

Activator-induced conformational changes regulate division-associated peptidoglycan amidases
por: Cook, Jonathan, et al.
Publicado: (2023)

Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N-acyltransferase
por: Smithers, Luke, et al.
Publicado: (2023)

Pyrophosphate Stimulates Differentiation, Matrix Gene Expression and Alkaline Phosphatase Activity in Osteoblasts
por: Pujari-Palmer, Michael, et al.
Publicado: (2016)

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis
por: Zhu, Jinsheng, et al.
Publicado: (2019)

In meso in situ serial X-ray crystallography of soluble and membrane proteins
por: Huang, Chia-Ying, et al.
Publicado: (2015)

Reaction mechanism of the farnesyl pyrophosphate C-methyltransferase towards the biosynthesis of pre-sodorifen pyrophosphate by Serratia plymuthica 4Rx13
por: Lemfack, Marie Chantal, et al.
Publicado: (2021)

Regulation of Polar Peptidoglycan Biosynthesis by Wag31 Phosphorylation in Mycobacteria
por: Jani, Charul, et al.
Publicado: (2010)

Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis
por: Hernández-Rocamora, Víctor M., et al.
Publicado: (2018)

Alkaline Phosphatases Account for Low Plasma Levels of Inorganic Pyrophosphate in Chronic Kidney Disease
por: Laurain, Audrey, et al.
Publicado: (2020)

Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis
por: Olatunji, Samir, et al.
Publicado: (2021)

Mechanisms of Incorporation for D-Amino Acid Probes That Target Peptidoglycan Biosynthesis
por: Kuru, Erkin, et al.
Publicado: (2019)

Imbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes
por: Schulz, Lisa Maria, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nsov8j948hpfdqul0hjthe61oq