A non-conserved amino acid variant regulates differential signalling between human and mouse CD28

CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic inflammatory response syndrome in humans, thereby implyin...

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Detalles Bibliográficos
Autores principales: Porciello, Nicla, Grazioli, Paola, Campese, Antonio F., Kunkl, Martina, Caristi, Silvana, Mastrogiovanni, Marta, Muscolini, Michela, Spadaro, Francesca, Favre, Cédric, Nunès, Jacques A., Borroto, Aldo, Alarcon, Balbino, Screpanti, Isabella, Tuosto, Loretta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852078/
https://www.ncbi.nlm.nih.gov/pubmed/29540686
http://dx.doi.org/10.1038/s41467-018-03385-8

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