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Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects

Insulin plays a central role in glucose homeostasis, and impairment of insulin action causes glucose intolerance and leads to type 2 diabetes mellitus (T2DM). A decrease in the transient peak and sustained increase of circulating insulin following an infusion of glucose accompany T2DM pathogenesis....

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Detalles Bibliográficos
Autores principales:	Ohashi, Kaoru, Fujii, Masashi, Uda, Shinsuke, Kubota, Hiroyuki, Komada, Hisako, Sakaguchi, Kazuhiko, Ogawa, Wataru, Kuroda, Shinya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852153/ https://www.ncbi.nlm.nih.gov/pubmed/29560274 http://dx.doi.org/10.1038/s41540-018-0051-6

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