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Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor
Hydrogen peroxide (H(2)O(2)) is an important signaling molecule in plant developmental processes and stress responses. However, whether H(2)O(2)-mediated signaling crosstalks with plant hormone signaling is largely unclear. Here, we show that H(2)O(2) induces the oxidation of the BRASSINAZOLE-RESIST...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852159/ https://www.ncbi.nlm.nih.gov/pubmed/29540799 http://dx.doi.org/10.1038/s41467-018-03463-x |
Sumario: | Hydrogen peroxide (H(2)O(2)) is an important signaling molecule in plant developmental processes and stress responses. However, whether H(2)O(2)-mediated signaling crosstalks with plant hormone signaling is largely unclear. Here, we show that H(2)O(2) induces the oxidation of the BRASSINAZOLE-RESISTANT1 (BZR1) transcription factor, which functions as a master regulator of brassinosteroid (BR) signaling. Oxidative modification enhances BZR1 transcriptional activity by promoting its interaction with key regulators in the auxin-signaling and light-signaling pathways, including AUXIN RESPONSE FACTOR6 (ARF6) and PHYTOCHROME INTERACTING FACTOR4 (PIF4). Genome-wide analysis shows that H(2)O(2)-dependent regulation of BZR1 activity plays a major role in modifying gene expression related to several BR-mediated biological processes. Furthermore, we show that the thioredoxin TRXh5 can interact with BZR1 and catalyzes its reduction. We conclude that reversible oxidation of BZR1 connects H(2)O(2)-mediated and thioredoxin-mediated redox signaling to BR signaling to regulate plant development. |
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