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Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor

Hydrogen peroxide (H(2)O(2)) is an important signaling molecule in plant developmental processes and stress responses. However, whether H(2)O(2)-mediated signaling crosstalks with plant hormone signaling is largely unclear. Here, we show that H(2)O(2) induces the oxidation of the BRASSINAZOLE-RESIST...

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Autores principales: Tian, Yanchen, Fan, Min, Qin, Zhaoxia, Lv, Hongjun, Wang, Minmin, Zhang, Zhe, Zhou, Wenying, Zhao, Na, Li, Xiaohui, Han, Chao, Ding, Zhaojun, Wang, Wenfei, Wang, Zhi-Yong, Bai, Ming-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852159/
https://www.ncbi.nlm.nih.gov/pubmed/29540799
http://dx.doi.org/10.1038/s41467-018-03463-x
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author Tian, Yanchen
Fan, Min
Qin, Zhaoxia
Lv, Hongjun
Wang, Minmin
Zhang, Zhe
Zhou, Wenying
Zhao, Na
Li, Xiaohui
Han, Chao
Ding, Zhaojun
Wang, Wenfei
Wang, Zhi-Yong
Bai, Ming-Yi
author_facet Tian, Yanchen
Fan, Min
Qin, Zhaoxia
Lv, Hongjun
Wang, Minmin
Zhang, Zhe
Zhou, Wenying
Zhao, Na
Li, Xiaohui
Han, Chao
Ding, Zhaojun
Wang, Wenfei
Wang, Zhi-Yong
Bai, Ming-Yi
author_sort Tian, Yanchen
collection PubMed
description Hydrogen peroxide (H(2)O(2)) is an important signaling molecule in plant developmental processes and stress responses. However, whether H(2)O(2)-mediated signaling crosstalks with plant hormone signaling is largely unclear. Here, we show that H(2)O(2) induces the oxidation of the BRASSINAZOLE-RESISTANT1 (BZR1) transcription factor, which functions as a master regulator of brassinosteroid (BR) signaling. Oxidative modification enhances BZR1 transcriptional activity by promoting its interaction with key regulators in the auxin-signaling and light-signaling pathways, including AUXIN RESPONSE FACTOR6 (ARF6) and PHYTOCHROME INTERACTING FACTOR4 (PIF4). Genome-wide analysis shows that H(2)O(2)-dependent regulation of BZR1 activity plays a major role in modifying gene expression related to several BR-mediated biological processes. Furthermore, we show that the thioredoxin TRXh5 can interact with BZR1 and catalyzes its reduction. We conclude that reversible oxidation of BZR1 connects H(2)O(2)-mediated and thioredoxin-mediated redox signaling to BR signaling to regulate plant development.
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spelling pubmed-58521592018-03-16 Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor Tian, Yanchen Fan, Min Qin, Zhaoxia Lv, Hongjun Wang, Minmin Zhang, Zhe Zhou, Wenying Zhao, Na Li, Xiaohui Han, Chao Ding, Zhaojun Wang, Wenfei Wang, Zhi-Yong Bai, Ming-Yi Nat Commun Article Hydrogen peroxide (H(2)O(2)) is an important signaling molecule in plant developmental processes and stress responses. However, whether H(2)O(2)-mediated signaling crosstalks with plant hormone signaling is largely unclear. Here, we show that H(2)O(2) induces the oxidation of the BRASSINAZOLE-RESISTANT1 (BZR1) transcription factor, which functions as a master regulator of brassinosteroid (BR) signaling. Oxidative modification enhances BZR1 transcriptional activity by promoting its interaction with key regulators in the auxin-signaling and light-signaling pathways, including AUXIN RESPONSE FACTOR6 (ARF6) and PHYTOCHROME INTERACTING FACTOR4 (PIF4). Genome-wide analysis shows that H(2)O(2)-dependent regulation of BZR1 activity plays a major role in modifying gene expression related to several BR-mediated biological processes. Furthermore, we show that the thioredoxin TRXh5 can interact with BZR1 and catalyzes its reduction. We conclude that reversible oxidation of BZR1 connects H(2)O(2)-mediated and thioredoxin-mediated redox signaling to BR signaling to regulate plant development. Nature Publishing Group UK 2018-03-14 /pmc/articles/PMC5852159/ /pubmed/29540799 http://dx.doi.org/10.1038/s41467-018-03463-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tian, Yanchen
Fan, Min
Qin, Zhaoxia
Lv, Hongjun
Wang, Minmin
Zhang, Zhe
Zhou, Wenying
Zhao, Na
Li, Xiaohui
Han, Chao
Ding, Zhaojun
Wang, Wenfei
Wang, Zhi-Yong
Bai, Ming-Yi
Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor
title Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor
title_full Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor
title_fullStr Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor
title_full_unstemmed Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor
title_short Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor
title_sort hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the brassinazole-resistant1 transcription factor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852159/
https://www.ncbi.nlm.nih.gov/pubmed/29540799
http://dx.doi.org/10.1038/s41467-018-03463-x
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