Characterization of antimicrobial and hemolytic properties of short synthetic cationic lipopeptides based on QSAR/QSTR approach

In this study, we investigated the influence of molecular descriptors of cationic lipopeptides on their antimicrobial activity and hemolytic properties. The quantitative structure–activity relationship and quantitative structure–property relationship models were constructed. The antimicrobial, hemol...

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Detalles Bibliográficos
Autores principales: Greber, Katarzyna E., Ciura, Krzesimir, Belka, Mariusz, Kawczak, Piotr, Nowakowska, Joanna, Bączek, Tomasz, Sawicki, Wiesław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852172/
https://www.ncbi.nlm.nih.gov/pubmed/29264738
http://dx.doi.org/10.1007/s00726-017-2530-2
Descripción
Sumario:In this study, we investigated the influence of molecular descriptors of cationic lipopeptides on their antimicrobial activity and hemolytic properties. The quantitative structure–activity relationship and quantitative structure–property relationship models were constructed. The antimicrobial, hemolytic and retention data were used as dependent variable and structural parameters as the independent ones. The obtained results suggest that the chromatographic indexes can be employed for prediction of antibacterial activity and that lipopeptides present nonspecific interaction between erythrocytes and bacterial membranes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00726-017-2530-2) contains supplementary material, which is available to authorized users.

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