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The β6/β7 region of the Hsp70 substrate-binding domain mediates heat-shock response and prion propagation
Hsp70 is a highly conserved chaperone that in addition to providing essential cellular functions and aiding in cell survival following exposure to a variety of stresses is also a key modulator of prion propagation. Hsp70 is composed of a nucleotide-binding domain (NBD) and substrate-binding domain (...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852193/ https://www.ncbi.nlm.nih.gov/pubmed/29124308 http://dx.doi.org/10.1007/s00018-017-2698-3 |