Role of the microenvironment in myeloid malignancies

The bone marrow microenvironment (BMM) regulates the fate of hematopoietic stem cells (HSCs) in homeostatic and pathologic conditions. In myeloid malignancies, new insights into the role of the BMM and its cellular and molecular actors in the progression of the diseases have started to emerge. In th...

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Detalles Bibliográficos
Autores principales: Goulard, Marie, Dosquet, Christine, Bonnet, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852194/
https://www.ncbi.nlm.nih.gov/pubmed/29222645
http://dx.doi.org/10.1007/s00018-017-2725-4
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author Goulard, Marie
Dosquet, Christine
Bonnet, Dominique
author_facet Goulard, Marie
Dosquet, Christine
Bonnet, Dominique
author_sort Goulard, Marie
collection PubMed
description The bone marrow microenvironment (BMM) regulates the fate of hematopoietic stem cells (HSCs) in homeostatic and pathologic conditions. In myeloid malignancies, new insights into the role of the BMM and its cellular and molecular actors in the progression of the diseases have started to emerge. In this review, we will focus on describing the major players of the HSC niche and the role of the altered niche function in myeloid malignancies, more specifically focusing on the mesenchymal stroma cell compartment.
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spelling pubmed-58521942018-03-21 Role of the microenvironment in myeloid malignancies Goulard, Marie Dosquet, Christine Bonnet, Dominique Cell Mol Life Sci Review The bone marrow microenvironment (BMM) regulates the fate of hematopoietic stem cells (HSCs) in homeostatic and pathologic conditions. In myeloid malignancies, new insights into the role of the BMM and its cellular and molecular actors in the progression of the diseases have started to emerge. In this review, we will focus on describing the major players of the HSC niche and the role of the altered niche function in myeloid malignancies, more specifically focusing on the mesenchymal stroma cell compartment. Springer International Publishing 2017-12-08 2018 /pmc/articles/PMC5852194/ /pubmed/29222645 http://dx.doi.org/10.1007/s00018-017-2725-4 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Goulard, Marie
Dosquet, Christine
Bonnet, Dominique
Role of the microenvironment in myeloid malignancies
title Role of the microenvironment in myeloid malignancies
title_full Role of the microenvironment in myeloid malignancies
title_fullStr Role of the microenvironment in myeloid malignancies
title_full_unstemmed Role of the microenvironment in myeloid malignancies
title_short Role of the microenvironment in myeloid malignancies
title_sort role of the microenvironment in myeloid malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852194/
https://www.ncbi.nlm.nih.gov/pubmed/29222645
http://dx.doi.org/10.1007/s00018-017-2725-4
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AT dosquetchristine roleofthemicroenvironmentinmyeloidmalignancies
AT bonnetdominique roleofthemicroenvironmentinmyeloidmalignancies

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