The voltage-gated sodium channel EF-hands form an interaction with the III-IV linker that is disturbed by disease-causing mutations

Voltage-gated sodium channels (Na(V)) are responsible for the rapid depolarization of many excitable cells. They readily inactivate, a process where currents diminish after milliseconds of channel opening. They are also targets for a multitude of disease-causing mutations, many of which have been sh...

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Detalles Bibliográficos
Autores principales: Gardill, Bernd R., Rivera-Acevedo, Ricardo E., Tung, Ching-Chieh, Okon, Mark, McIntosh, Lawrence P., Van Petegem, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852250/
https://www.ncbi.nlm.nih.gov/pubmed/29540853
http://dx.doi.org/10.1038/s41598-018-22713-y

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