Cargando…

Protein phosphatase 2A (PP2A) inhibitor CIP2A indicates resistance to radiotherapy in rectal cancer

Preoperative (chemo)radiotherapy, (C)RT, is an essential part of the treatment of rectal cancer patients, but tumor response to this therapy among patients is variable. Thus far, there are no clinical biomarkers that could be used to predict response to (C)RT or to stratify patients into different p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Birkman, Eva‐Maria, Elzagheid, Adam, Jokilehto, Terhi, Avoranta, Tuulia, Korkeila, Eija, Kulmala, Jarmo, Syrjänen, Kari, Westermarck, Jukka, Sundström, Jari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Clinical Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852361/ https://www.ncbi.nlm.nih.gov/pubmed/29441695 http://dx.doi.org/10.1002/cam4.1361

Ejemplares similares

Protein phosphatase methylesterase‐1 (PME‐1) expression predicts a favorable clinical outcome in colorectal cancer
por: Kaur, Amanpreet, et al.
Publicado: (2015)

Heterogeneous EGFR Gene Copy Number Increase Is Common in Colorectal Cancer and Defines Response to Anti-EGFR Therapy
por: Ålgars, Annika, et al.
Publicado: (2014)

CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance
por: Ventelä, Sami, et al.
Publicado: (2014)

ETS1 Mediates MEK1/2-Dependent Overexpression of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) in Human Cancer Cells
por: Khanna, Anchit, et al.
Publicado: (2011)

Protein interactome of the Cancerous Inhibitor of protein phosphatase 2A (CIP2A) in Th17 cells
por: Khan, Mohd Moin, et al.
Publicado: (2020)

MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers
por: Ventelä, Sami, et al.
Publicado: (2016)

Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer
por: Korkeila, E, et al.
Publicado: (2009)

Reply: expression of carbonic anhydrase IX suggests poor response to therapy in rectal cancer
por: Korkeila, E, et al.
Publicado: (2009)

Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
por: Pavic, Karolina, et al.
Publicado: (2023)

CIP2A Promotes Proliferation of Spermatogonial Progenitor Cells and Spermatogenesis in Mice
por: Ventelä, Sami, et al.
Publicado: (2012)

Arpp19 Promotes Myc and Cip2a Expression and Associates with Patient Relapse in Acute Myeloid Leukemia
por: Mäkelä, Eleonora, et al.
Publicado: (2019)

Chk1 Inhibition Ameliorates Alzheimer’s Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling
por: Hu, Wenting, et al.
Publicado: (2022)

Prognostic role of CIP2A expression in serous ovarian cancer
por: Böckelman, C, et al.
Publicado: (2011)

CIP2A Constrains Th17 Differentiation by Modulating STAT3 Signaling
por: Khan, Mohd Moin, et al.
Publicado: (2020)

Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling
por: Kauko, Otto, et al.
Publicado: (2015)

Ezrin expression combined with MSI status in prognostication of stage II colorectal cancer
por: Slik, Khadija, et al.
Publicado: (2017)

CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations
por: Khanna, Anchit, et al.
Publicado: (2015)

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease
por: Shentu, Yang-Ping, et al.
Publicado: (2018)

Over-expression of HER-2 is associated with the stage in carcinomas of the urinary bladder
por: El Gehani, Khaled, et al.
Publicado: (2012)

Erlotinib derivative inhibits hepatocellular carcinoma by targeting CIP2A to reactivate protein phosphatase 2A
por: Yu, H-C, et al.
Publicado: (2014)

Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): An oncoprotein with many hands
por: De, Pradip, et al.
Publicado: (2014)

CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection
por: Côme, Christophe, et al.
Publicado: (2016)

CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis
por: Laine, Anni, et al.
Publicado: (2021)

The role of HIF prolyl hydroxylases in tumour growth
por: Jokilehto, Terhi, et al.
Publicado: (2010)

Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson’s Disease?
por: Yin, Sijia, et al.
Publicado: (2022)

The combined effects of irradiation and herpes simplex virus type 1 infection on an immortal gingival cell line
por: Turunen, Aaro, et al.
Publicado: (2014)

From Basic Science to Clinical Practice: The Role of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A)/p90 in Cancer
por: Chen, Beibei, et al.
Publicado: (2023)

EGFR gene amplification is relatively common and associates with outcome in intestinal adenocarcinoma of the stomach, gastro-oesophageal junction and distal oesophagus
por: Birkman, Eva-Maria, et al.
Publicado: (2016)

Activation of cancerous inhibitor of PP2A (CIP2A) contributes to lapatinib resistance through induction of CIP2A-Akt feedback loop in ErbB2-positive breast cancer cells
por: Zhao, Ming, et al.
Publicado: (2017)

The concept of the okadaic acid class of tumor promoters is revived in endogenous protein inhibitors of protein phosphatase 2A, SET and CIP2A, in human cancers
por: Fujiki, Hirota, et al.
Publicado: (2018)

CIP2A expression is increased in prostate cancer
por: Vaarala, Markku H, et al.
Publicado: (2010)

RAS and PP2A activities converge on epigenetic gene regulation
por: Aakula, Anna, et al.
Publicado: (2023)

Monotherapy efficacy of blood–brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma
por: Merisaari, Joni, et al.
Publicado: (2020)

Angiogenesis in urinary bladder carcinoma as defined by microvessel density (MVD) after immunohistochemical staining for Factor VIII and CD31
por: El Gehani, Khaled, et al.
Publicado: (2011)

CIP2A overexpression in Taiwanese oral cancer patients
por: Velmurugan, Bharath Kumar, et al.
Publicado: (2019)

Gastric cancer: immunohistochemical classification of molecular subtypes and their association with clinicopathological characteristics
por: Birkman, Eva-Maria, et al.
Publicado: (2017)

Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an independent prognostic marker in wild-type KRAS metastatic colorectal cancer after colorectal liver metastasectomy
por: Chen, Kuen-Feng, et al.
Publicado: (2015)

Constitutive Cell Proliferation Regulating Inhibitor of Protein Phosphatase 2A (CIP2A) Mediates Drug Resistance to Erlotinib in an EGFR Activating Mutated NSCLC Cell Line
por: Saafan, Hisham, et al.
Publicado: (2021)

Combined epithelial marker analysis of tumour budding in stage II colorectal cancer
por: Slik, Khadija, et al.
Publicado: (2018)

CIP2A silencing alleviates doxorubicin resistance in MCF7/ADR cells through activating PP2A and autophagy
por: Zhu, Z., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8soiutp2trtu7a5qb8ipusa5bg