Cargando…

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress. We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the acetylenic tricyclic bis(cyano enone) TBE-31 would suppress NASH because Nrf2 is a transcriptional master regulator...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sharma, Ritu S., Harrison, David J., Kisielewski, Dorothy, Cassidy, Diane M., McNeilly, Alison D., Gallagher, Jennifer R., Walsh, Shaun V., Honda, Tadashi, McCrimmon, Rory J., Dinkova-Kostova, Albena T., Ashford, Michael L.J., Dillon, John F., Hayes, John D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852394/ https://www.ncbi.nlm.nih.gov/pubmed/29552625 http://dx.doi.org/10.1016/j.jcmgh.2017.11.016

Ejemplares similares

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance
por: Meakin, Paul J., et al.
Publicado: (2014)

Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes
por: McNeilly, Alison D., et al.
Publicado: (2023)

Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion
por: McNeilly, Alison D., et al.
Publicado: (2022)

Impaired hypoglycaemia awareness in type 1 diabetes: lessons from the lab
por: McNeilly, Alison D., et al.
Publicado: (2018)

Advances and Emerging Therapies in the Treatment of Non-alcoholic Steatohepatitis
por: Brennan, Paul N, et al.
Publicado: (2022)

High‐intensity training as a novel treatment for impaired awareness of hypoglycaemia in type 1 diabetes [HIT4HYPOS]: Protocol for a randomized parallel‐group study
por: Farrell, Catriona M., et al.
Publicado: (2020)

Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression
por: Morrice, Nicola, et al.
Publicado: (2023)

Real-time Continuous Glucose Monitoring During a Hyperinsulinemic-Hypoglycemic Clamp Significantly Underestimates the Degree of Hypoglycemia
por: Farrell, Catriona M., et al.
Publicado: (2020)

Reducing Glut2 throughout the body does not result in cognitive behaviour differences in aged male mice
por: Morrice, Nicola, et al.
Publicado: (2020)

In-vivo correlations between skin metabolic oscillations and vasomotion in wild-type mice and in a model of oxidative stress
por: Smirni, Salvatore, et al.
Publicado: (2019)

The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection
por: Chen, Changwei, et al.
Publicado: (2021)

The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response
por: Dinkova-Kostova, Albena T.
Publicado: (2012)

Nrf2 in TIME: The Emerging Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Tumor Immune Microenvironment
por: Feng, Jialin, et al.
Publicado: (2023)

A randomised controlled study of high intensity exercise as a dishabituating stimulus to improve hypoglycaemia awareness in people with type 1 diabetes: a proof-of-concept study
por: Farrell, Catriona M., et al.
Publicado: (2020)

Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis
por: Muha, Villő, et al.
Publicado: (2021)

The emerging role of Nrf2 in mitochondrial function
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2015)

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis
por: Robertson, Holly, et al.
Publicado: (2020)

Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia
por: Vickneson, Keeran, et al.
Publicado: (2021)

Consequences of recurrent hypoglycaemia on brain function in diabetes
por: McCrimmon, Rory J.
Publicado: (2021)

Remembrance of things past: The consequences of recurrent hypoglycaemia in diabetes
por: McCrimmon, Rory J.
Publicado: (2022)

The multifaceted role of Nrf2 in mitochondrial function
por: Holmström, Kira M., et al.
Publicado: (2016)

Glucose Sensing During Hypoglycemia: Lessons From the Lab
por: McCrimmon, Rory
Publicado: (2009)

Oleate induces K(ATP) channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge
por: Dadak, Selma, et al.
Publicado: (2017)

The role of Nrf2 signaling in counteracting neurodegenerative diseases
por: Dinkova‐Kostova, Albena T., et al.
Publicado: (2018)

Monitoring Keap1–Nrf2 interactions in single live cells
por: Baird, Liam, et al.
Publicado: (2014)

Hypoglycemia in Type 1 Diabetes
por: McCrimmon, Rory J., et al.
Publicado: (2010)

Does dapagliflozin regress left ventricular hypertrophy in patients with type 2 diabetes? A prospective, double-blind, randomised, placebo-controlled study
por: Brown, Alexander J.M., et al.
Publicado: (2017)

SGLT inhibitor adjunct therapy in type 1 diabetes
por: McCrimmon, Rory J., et al.
Publicado: (2018)

Clinical approaches to treat impaired awareness of hypoglycaemia
por: Farrell, Catriona M., et al.
Publicado: (2021)

NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis
por: Kahremany, Shirin, et al.
Publicado: (2022)

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2017)

The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2015)

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2020)

NRF2 as an Emerging Therapeutic Target
por: Copple, Ian M., et al.
Publicado: (2017)

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice
por: Muha, Villo, et al.
Publicado: (2019)

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma
por: Knatko, Elena V., et al.
Publicado: (2016)

An Estimate of Lifetime Cognitive Change and Its Relationship with Diabetes Health in Older Adults with Type 1 Diabetes: Preliminary Results
por: Johnston, Harriet, et al.
Publicado: (2010)

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells
por: Roubalová, Lenka, et al.
Publicado: (2017)

Type 2 diabetes, socioeconomic status and life expectancy in Scotland (2012–2014): a population-based observational study
por: Walker, Jeremy, et al.
Publicado: (2017)

Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_q3jpq097dbom5irf1u5d1b8ogk