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Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis
Corticosteroids are potent anti-inflammatory and anti-allergic agents used in the treatment of various inflammatory diseases, including allergic disease. They are frequently considered the therapy-of-choice for many skin diseases. However, allergic reactions caused by corticosteroids have been repor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852418/ https://www.ncbi.nlm.nih.gov/pubmed/29542298 http://dx.doi.org/10.3346/jkms.2018.33.e87 |
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author | Son, Jee Hee Park, Sook Young Cho, Yong Se Chung, Bo Young Kim, Hye One Park, Chun Wook |
author_facet | Son, Jee Hee Park, Sook Young Cho, Yong Se Chung, Bo Young Kim, Hye One Park, Chun Wook |
author_sort | Son, Jee Hee |
collection | PubMed |
description | Corticosteroids are potent anti-inflammatory and anti-allergic agents used in the treatment of various inflammatory diseases, including allergic disease. They are frequently considered the therapy-of-choice for many skin diseases. However, allergic reactions caused by corticosteroids have been reported. Among these, delayed reactions to topical steroids are more common, whereas immediate reactions to systemic steroids are rare. Herein, we report the case of a 32-year-old woman with triamcinolone-induced immediate hypersensitivity reaction, in which the patient had a positive prick test result with triamcinolone. She has had atopic dermatitis (AD) for three years. She had used systemic steroid, cyclosporine, and antihistamine with topical steroids for AD. In clinic, approximately 10 minutes after intralesional injection of triamcinolone, she complained of erythematous patches with slight elevation and itching on the face, trunk, and both hands. After intravenous injection of dexamethasone, her symptoms got worse. After treatment with epinephrine, all symptoms resolved within two hours. We performed an open test and skin prick test. She had a positive result only from the prick test with triamcinolone; all other steroids showed negative results from the open tests. Dermatologists should be aware of the possibility of anaphylaxis or other allergic hypersensitivity in response to corticosteroids. |
format | Online Article Text |
id | pubmed-5852418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-58524182018-03-19 Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis Son, Jee Hee Park, Sook Young Cho, Yong Se Chung, Bo Young Kim, Hye One Park, Chun Wook J Korean Med Sci Case Report Corticosteroids are potent anti-inflammatory and anti-allergic agents used in the treatment of various inflammatory diseases, including allergic disease. They are frequently considered the therapy-of-choice for many skin diseases. However, allergic reactions caused by corticosteroids have been reported. Among these, delayed reactions to topical steroids are more common, whereas immediate reactions to systemic steroids are rare. Herein, we report the case of a 32-year-old woman with triamcinolone-induced immediate hypersensitivity reaction, in which the patient had a positive prick test result with triamcinolone. She has had atopic dermatitis (AD) for three years. She had used systemic steroid, cyclosporine, and antihistamine with topical steroids for AD. In clinic, approximately 10 minutes after intralesional injection of triamcinolone, she complained of erythematous patches with slight elevation and itching on the face, trunk, and both hands. After intravenous injection of dexamethasone, her symptoms got worse. After treatment with epinephrine, all symptoms resolved within two hours. We performed an open test and skin prick test. She had a positive result only from the prick test with triamcinolone; all other steroids showed negative results from the open tests. Dermatologists should be aware of the possibility of anaphylaxis or other allergic hypersensitivity in response to corticosteroids. The Korean Academy of Medical Sciences 2018-02-13 /pmc/articles/PMC5852418/ /pubmed/29542298 http://dx.doi.org/10.3346/jkms.2018.33.e87 Text en © 2018 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Son, Jee Hee Park, Sook Young Cho, Yong Se Chung, Bo Young Kim, Hye One Park, Chun Wook Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis |
title | Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis |
title_full | Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis |
title_fullStr | Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis |
title_full_unstemmed | Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis |
title_short | Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis |
title_sort | immediate hypersensitivity reactions induced by triamcinolone in a patient with atopic dermatitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852418/ https://www.ncbi.nlm.nih.gov/pubmed/29542298 http://dx.doi.org/10.3346/jkms.2018.33.e87 |
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